...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Occupational and environmental medicine >Incidence of dimethylacetamide induced hepatic injury among new employees in a cohort of elastane fibre workers.
【24h】

Incidence of dimethylacetamide induced hepatic injury among new employees in a cohort of elastane fibre workers.

机译：在一组弹性纤维工人中，新员工中二甲基乙酰胺引起的肝损伤。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE: To investigate the incidence of N,N-dimethylacetamide (DMA) induced hepatic injury among new elastane fibre workers and to explore factors relating to DMA induced hepatic injury. METHODS: Elastane fibre workers exposed to DMA were monitored for hepatic injury. Four hundred and forty new workers employed from 1 January 2002 to 31 July 2004 were included as study subjects. DMA exposure estimates were based on urinary N-methylacetamide (NMA) concentrations. RESULTS: There were 28 cases of DMA induced hepatic injury. The overall incidence of DMA induced hepatic injury among new elastane fibre workers was 0.089/person-year. Incidence rates were 7-10 times higher in high exposure groups than in low exposure groups. Fewer DMA induced hepatic injuries occurred among workers employed for a longer period. Workers whose exposure duration was more than seven months showed no hepatic injury in either the high or low exposure groups. Exposure category and duration of employment were significant variables in the multiple logistic regression analysis. CONCLUSIONS: Results suggest the existence of dose dependent DMA induced hepatic injury. The inverse relation between the incidence of DMA induced hepatic injury and duration of employment may reflect a type of healthy survivor effect or tolerance to DMA induced hepatic injury.
机译：目的：探讨N，N-二甲基乙酰胺（DMA）引起的新的弹性纤维工人肝损伤的发生率，并探讨与DMA引起的肝损伤相关的因素。方法：对暴露于DMA的弹性纤维工人进行肝损伤监测。从2002年1月1日至2004年7月31日雇用的440名新工人被纳入研究对象。 DMA暴露估算基于尿液中N-甲基乙酰胺（NMA）浓度。结果：28例DMA引起的肝损伤。 DMA在新的弹性纤维工人中引起的肝损伤的总发生率为0.089 /人年。高暴露组的发生率比低暴露组高7-10倍。受雇时间较长的工人中，DMA引起的肝损伤的发生率降低。在高或低暴露组中，暴露持续时间超过七个月的工人均未显示肝损伤。暴露类别和就业时间是多元逻辑回归分析中的重要变量。结论：结果表明存在剂量依赖性DMA诱导的肝损伤。 DMA诱发的肝损伤的发生率与工作时间之间的反比关系可能反映出健康的幸存者效应或对DMA诱发的肝损伤的耐受性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号