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首页> 外文期刊>Occupational and environmental medicine >A time-series study of the health effects of water-soluble and total-extractable metal content of airborne particulate matter.
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A time-series study of the health effects of water-soluble and total-extractable metal content of airborne particulate matter.

机译：空气中颗粒物的水溶性和总可提取金属含量对健康的影响的时间序列研究。

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OBJECTIVES: To assess whether adverse acute cardiopulmonary health outcomes are associated with concentration of trace metals in airborne particulate matter. METHODS: Daily PM(10) and PM(2.5) were collected for 1 year in Edinburgh, UK, and the water-soluble and total-extractable content of 11 trace metals determined in each sample. Time series were analysed using generalised additive Poisson regression models, including adjustment for minimum temperature and less smoothing of trends. Methods were explored of extending the time series of metal concentration in daily PM(10) for the previous 7 years using multiple regression of the variation in metal content for the 1 year of measurements and the associated variation in air mass source region and other concurrently-measured potential predictor variables. RESULTS: The 1 year of direct measurements showed no evidence of significant associations of particle-bound metal concentration with health outcomes beyond that expected by chance. Analysis of the extended time series showed significant positive associations with cardiovascular admissions both for total PM(10) and for a number of the metals (eg, Cu, Fe, Ni, V, Zn) but the metal effects were no longer significant after adjusting for PM(10). CONCLUSIONS: Within the limitations of the study power, the epidemiological results have not provided evidence for associations between particle-bound metal concentrations and adverse health outcomes that are substantially greater than for total PM. The generally strong correlations between metal and total PM suggest that quantifying independent effects of PM metal exposure on health will be difficult, even using more powerful time series of direct measurements.
机译：目的：评估不良急性心肺健康结果是否与空气中颗粒物中微量金属的浓度有关。方法：在英国爱丁堡收集1年的每日PM（10）和PM（2.5），并测定每个样品中11种微量金属的水溶性和总可萃取含量。使用广义加性Poisson回归模型分析了时间序列，包括调整最低温度和减少趋势平滑。探索了使用1年测量中金属含量变化的多重回归以及相关的空气质量源区域变化和其他同时变化来扩展前7年每日PM（10）中金属浓度的时间序列的方法-测量的潜在预测变量。结果：1年的直接测量结果表明，没有证据表明结合颗粒的金属浓度与健康结果之间的显着关联超出了偶然的预期。延长时间序列的分析显示，总PM（10）和许多金属（例如，铜，铁，镍，钒，锌）与心血管疾病的入院率呈显着正相关，但调整后金属效应不再显着对于PM（10）。结论：在研究能力的限制内，流行病学结果尚未提供证据表明结合颗粒的金属浓度与不利健康结果之间的关联性明显大于总PM。金属与总PM之间通常存在很强的相关性，即使使用更强大的直接测量时间序列，也难以量化PM金属暴露对健康的独立影响。

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