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首页> 外文期刊>Occupational and environmental medicine >Cancer risk for chemical workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin.
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Cancer risk for chemical workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

机译：化学工作者接触2,3,7,8-四氯二苯并-对-二恶英的癌症风险。

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AIMS: To describe the long term mortality experience of a cohort of 2187 male chemical production workers previously exposed to substantial levels of dioxin. METHODS: Vital status for a previously identified cohort was determined for an additional 10 years, to 1995. Dioxin exposures took place before 1983 and were sufficient to result in chloracne in 245 individuals. Mortality rates were compared with national figures and with a large pool of co-workers in unrelated production jobs. RESULTS: All cancers combined (standardised mortality ratio (SMR) = 1.0, 95% CI 0.8 to 1.1) and lung cancer (SMR = 0.8, 95% CI 0.6 to 1.1) were at or below expected levels. Rates for soft tissue sarcoma (SMR = 2.4, 95% CI 0.3 to 8.6) and non-Hodgkin's lymphoma (SMR = 1.4, 95% CI 0.6 to 2.7) were greater than expected overall, but below expectation in the update period. No trend of increasing risk with increasing exposure was observed for these cancers. Workers who developed chloracne had very low all-cancer rates (SMR = 0.5, 95% CI 0.3 to 1.0), and lung cancer rates (SMR = 0.3, 95% CI 0.0 to 1.1). CONCLUSIONS: We found no coherent evidence of increased cancer risk from dioxin exposure in this cohort. Our study highlights the wide range of cancer rates and the lack of consistency across dioxin studies.
机译：目的：描述2187名先前接触大量二恶英的男性化学生产工人的长期死亡率。方法：确定以前确定的队列的生命状态，再延长10年，直到1995年。二恶英暴露发生于1983年之前，足以导致245个人中的并六氯苯胺。将死亡率与国家数据以及大量从事无关生产工作的同事进行了比较。结果：所有合并的癌症（标准死亡率（SMR）= 1.0，95％CI 0.8到1.1）和肺癌（SMR = 0.8，95％CI 0.6到1.1）均在或低于预期水平。软组织肉瘤（SMR = 2.4，95％CI 0.3至8.6）和非霍奇金淋巴瘤（SMR = 1.4，95％CI 0.6至2.7）的发生率均高于总体预期，但在更新期间低于预期。对于这些癌症，未观察到随着暴露增加而增加风险的趋势。罹患氯痤疮的工人的全癌发病率非常低（SMR = 0.5，95％CI为0.3至1.0），肺癌的发病率（SMR = 0.3，95％CI为0.0至1.1）。结论：在该队列中，我们没有相关的证据表明二恶英暴露会增加患癌症的风险。我们的研究强调了二恶英研究的广泛癌症发生率和缺乏一致性。

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