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首页> 外文期刊>Occupational and environmental medicine >DNA-protein crosslinks and p53 protein expression in relation to occupational exposure to formaldehyde.
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DNA-protein crosslinks and p53 protein expression in relation to occupational exposure to formaldehyde.

机译：与甲醛职业接触有关的DNA-蛋白质交联和p53蛋白表达。

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BACKGROUND: Formaldehyde (FA) is classified as a probable human carcinogen. AIMS: To examine DNA protein crosslinks (DPC) and p53, which are generally known to be involved in carcinogenesis, in peripheral blood lymphocytes of workers exposed to FA. METHODS: DPC and p53 ("wild type" and mutant) were examined in peripheral blood lymphocytes of 186 workers exposed to FA (mean years of exposure = 16) and 213 unexposed workers. Every worker completed a questionnaire on demographic data, occupational and medical history, smoking, and hygiene. RESULTS: The adjusted mean level of DPC in the exposed and the unexposed workers differed significantly. Adjustment was made for age, sex, years of education, smoking, and origin. Exposure to FA increased the risk of having a higher level of pantropic p53 above 150 pg/ml (OR 1.6, 95% CI 0.8 to 3.1). A significant positive correlation was found between the increase of pantropic p53 protein and mutant p53 protein, as well as between pantropic p53 >150 pg/ml and mutant p53protein. In the exposed group a significantly higher proportion of p53 >150 pg/ml was found among workers with DPC >0.187 (55.7%) (0.187 = median level of DPC) than among workers with DPC < or =0.187 (33.3%). The risk of having pantropic p53 protein >150 pg/ml was determined mainly by levels of DPC. Workers with DPC above the median level had a significantly higher risk of having pantropic p53 >150 pg/ml (adjusted OR 2.5, 95% CI 1.2 to 5.4). CONCLUSIONS: Results suggest that DPC and mutation in p53 may represent steps in FA carcinogenesis and a possible causal relation between DPC and mutation in p53. These biomarkers can be applied in the assessment of the development of cancer due to FA exposure.
机译：背景：甲醛（FA）被归类为可能的人类致癌物。目的：研究接触FA的工人外周血淋巴细胞中通常已知与致癌作用有关的DNA蛋白交联（DPC）和p53。方法：在186名暴露于FA的工人（平均暴露年数= 16）和213名未暴露的工人的外周血淋巴细胞中检测了DPC和p53（“野生型”和突变体）。每个工人都完成了有关人口统计数据，职业和病史，吸烟和卫生状况的问卷调查。结果：暴露工人和未暴露工人的DPC调整后平均水平存在显着差异。调整了年龄，性别，受教育年限，吸烟和出身。暴露于FA会增加泛函p53含量高于150 pg / ml的风险（OR 1.6，95％CI 0.8至3.1）。发现泛嗜性p53蛋白和突变体p53蛋白的增加之间以及泛嗜性p53> 150 pg / ml与突变体p53蛋白之间存在显着正相关。在暴露组中，发现DPC> 0.187的工人中p53> 150 pg / ml的比例显着高于DPC <或= 0.187的工人（33.3％）中的p53> 150 pg / ml。泛嗜性p53蛋白> 150 pg / ml的风险主要由DPC水平决定。 DPC高于中值水平的工人罹患泛嗜性p53> 150 pg / ml的风险显着更高（调整后的OR 2.5，95％CI 1.2至5.4）。结论：结果表明，p53中的DPC和突变可能代表FA致癌的步骤，以及p53中DPC和突变之间的可能因果关系。这些生物标记物可用于评估由于FA暴露引起的癌症发展。

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