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首页> 外文期刊>Occupational and environmental medicine >Lymphohaematopoietic system cancer incidence in an urban area near a coke oven plant: an ecological investigation.
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Lymphohaematopoietic system cancer incidence in an urban area near a coke oven plant: an ecological investigation.

机译：焦炉厂附近市区的淋巴造血系统癌症发生率：一项生态调查。

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摘要

AIMS: To evaluate the incidence risk of lymphohaematopoietic cancers for the 1986-94 period in Cornigliano, a district of Genoa (Italy), where a coke oven is located a few hundred metres from the residential area. METHODS: The whole of Genoa and one of its 25 districts (Rivarolo) were selected as controls. The trend of risk around the coke oven was evaluated via Stone's method, while the geographic pattern of such risks across the Cornigliano district was evaluated by computing full Bayes estimates of standardised incidence ratio (FBE-SIR). RESULTS: In males, elevated relative risks (RR) were observed for all lymphohaematopoietic cancers (RR 1.7 v Rivarolo and 1.6 v Genoa), for NHL (RR 2.4 v Rivarolo and 1.7 v Genoa), and for leukaemia (RR 2.4 v Rivarolo and 1.9 v Genoa). In females, statistically non-significant RR were observed. In males no excess of risk was found close to the coke oven. In females, a rising risk for NHL was observed approaching the plant, although statistical significance was not reached, while the risk for leukaemia was not evaluable due to the small number of cases. Analysis of the geographic pattern of risk suggested the presence of a cluster of NHL in both sexes in the eastern part of the district, where a foundry had been operational until the early 1980s. A cluster of leukaemia cases was observed in males in a northern part of the area, where no major sources of benzene seemed to be present. CONCLUSIONS: The estimated risks seem to be slightly or not at all related to the distance from the coke oven. The statistically significant higher risks observed in males for NHL and leukaemia, and the clusters of leukaemia in males and of NHL in both sexes deserve further investigations in order to trace the exposures associated with such risks.
机译：目的：评估在热那亚（意大利）科尼利亚诺（Cornigliano）1986-94年期间发生淋巴造血系统癌症的风险，该地区距离居民区几百米处有一个焦炉。方法：选择整个热那亚及其25个区之一（Rivarolo）作为对照。焦炉周围的风险趋势通过Stone方法进行了评估，而整个Cornigliano地区的此类风险的地理格局则通过计算标准发生率的完整贝叶斯估计（FBE-SIR）进行了评估。结果：在男性中，所有淋巴造血系统癌症（RR 1.7对Rivarolo和1.6 v Genoa），NHL（RR 2.4对Rivarolo和1.7 v Genoa）和白血病（RR 2.4对Rivarolo和RR）的相对风险（RR）升高。 1.9 v热那亚）。在女性中，观察到统计学上无统计学意义的RR。在男性中，在焦炉附近未发现过多风险。在女性中，虽然未达到统计学显着性，但观察到接近植物的NHL风险上升，而由于病例数少，无法评估白血病的风险。对风险的地理格局的分析表明，该地区的东部地区存在着两性的NHL人群，该地区的铸造厂一直运营到1980年代初。在该地区北部的男性中观察到一系列白血病病例，那里似乎没有主要的苯来源。结论：估计的风险似乎与距焦炉的距离略有或完全没有关系。男性中观察到的NHL和白血病风险较高，具有统计学意义，而男性中的白血病群和男女中的NHL人群均应作进一步调查，以追踪与此类风险相关的暴露程度。

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