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首页> 外文期刊>Occupational and environmental medicine >Repeated daily exposure to 2 ppm nitrogen dioxide upregulates the expression of IL-5, IL-10, IL-13, and ICAM-1 in the bronchial epithelium of healthy human airways.
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Repeated daily exposure to 2 ppm nitrogen dioxide upregulates the expression of IL-5, IL-10, IL-13, and ICAM-1 in the bronchial epithelium of healthy human airways.

机译：每天重复暴露于2 ppm二氧化氮会上调健康人气道支气管上皮中IL-5，IL-10，IL-13和ICAM-1的表达。

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BACKGROUND: Repeated daily exposure of healthy human subjects to NO2 induces an acute airway inflammatory response characterised by neutrophil influx in the bronchial mucosa AIMS: To assess the expression of NF-kappaB, cytokines, and ICAM-1 in the bronchial epithelium. METHODS: Twelve healthy, young non-smoking volunteers were exposed to 2 ppm of NO2/filtered air (four hours/day) for four successive days on separate occasions. Fibreoptic bronchoscopy was performed one hour after air and final NO2 exposures. Bronchial biopsy specimens were immunostained for NF-kappaB, TNF-alpha, eotaxin, Gro-alpha, GM-CSF, IL-5, -6, -8, -10, -13, and ICAM-1 and their expression was quantified using computerised image analysis. RESULTS: Expression of IL-5, IL-10, IL-13, and ICAM-1 increased following NO2 exposure. CONCLUSION: Upregulation of the Th2 cytokines suggests that repeated exposure to NO2 has the potential to exert a "pro-allergic" effect on the bronchial epithelium. Upregulation of ICAM-1 highlights an underlying mechanism for leucocyte influx, and could also explain the predisposition to respiratory tract viral infections following NO2 exposure since ICAM-1 is a major receptor for rhino and respiratory syncytial viruses.
机译：背景：健康人每天反复暴露于NO2会诱发急性气道炎症反应，其特征是支气管黏膜中性粒细胞大量流入。目的：评估NF-κB，细胞因子和ICAM-1在支气管上皮细胞中的表达。方法：十二名健康，年轻的非吸烟志愿者分别在连续的四天中连续2天暴露于2 ppm的NO2 /过滤空气中（四小时/天）。空气和最终暴露于NO2一小时后进行纤维支气管镜检查。对支气管活检标本进行了NF-κB，TNF-α，嗜酸性粒细胞趋化因子，Gro-α，GM-CSF，IL-5，-6，-8，-10，-13和ICAM-1的免疫染色，并使用计算机图像分析。结果：暴露于NO2后，IL-5，IL-10，IL-13和ICAM-1的表达增加。结论：Th2细胞因子的上调表明，反复暴露于NO2可能会对支气管上皮产生“促过敏”作用。 ICAM-1的上调突出了白细胞大量涌入的潜在机制，也可能解释了NO2暴露后呼吸道病毒感染的易感性，因为ICAM-1是犀牛和呼吸道合胞病毒的主要受体。

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