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首页> 外文期刊>Occupational and environmental medicine >Mortality among British asbestos workers undergoing regular medical examinations (1971-2005).
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Mortality among British asbestos workers undergoing regular medical examinations (1971-2005).

机译：接受定期体检的英国石棉工人的死亡率（1971-2005年）。

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OBJECTIVES: The Great Britain Asbestos Survey was established to monitor mortality among workers covered by regulations to control occupational exposure to asbestos. This study updates the estimated burden of asbestos-related mortality in the cohort, and identifies risk factors associated with mortality. METHODS: From 1971, workers were recruited during initially voluntary and later statutory medical examinations. A brief questionnaire was completed during the medical, and participants were flagged for death registrations. Standardised mortality ratios (SMRs) and proportional mortality ratios (PMRs) were calculated for deaths occurring before 2006. Poisson regression analyses were undertaken for diseases with significant excess mortality. RESULTS: There were 15 496 deaths among 98 117 workers followed-up for 1 779 580 person-years. The SMR for all cause mortality was 141 (95% CI 139 to 143) and for all malignant neoplasms 163 (95% CI 159 to 167). The SMRs for cancers of the stomach (166), lung (187), peritoneum (3730) and pleura (968), mesothelioma (513), cerebrovascular disease (164) and asbestosis (5594) were statistically significantly elevated, as were the corresponding PMRs. In age and sex adjusted analysis, birth cohort, age at first exposure, year of first exposure, duration of exposure, latency and job type were associated with the relative risk of lung, pleural and peritoneal cancers, asbestosis and mesothelioma mortality. CONCLUSIONS: Known associations between asbestos exposure and mortality from lung, peritoneal and pleural cancers, mesothelioma and asbestosis were confirmed, and evidence of associations with stroke and stomach cancer mortality was observed. Limited evidence suggested that asbestos-related disease risk may be lower among those first exposed in more recent times.
机译：目的：建立英国石棉调查旨在监测受法规控制的工人对石棉职业接触的死亡率。这项研究更新了队列中与石棉有关的死亡率的估计负担，并确定了与死亡率相关的危险因素。方法：从1971年开始，在最初的自愿医疗检查和后来的法定医疗检查中招募了工人。在医疗过程中完成了简短的问卷调查，并标记了参加者的死亡登记。计算了2006年之前发生的死亡的标准死亡率（SMR）和比例死亡率（PMR）。对严重过高的疾病进行了泊松回归分析。结果：98 117名工人中有15 496人死亡，其随访时间为1 779 580人年。所有原因死亡的SMR为141（95％CI 139至143），所有恶性肿瘤为163（95％CI 159至167）。胃癌（166），肺癌（187），腹膜（3730）和胸膜（968），间皮瘤（513），脑血管疾病（164）和石棉沉着症（5594）的SMR值在统计学上显着升高，相应的PMR。在年龄和性别校正分析中，出生队列，初次接触的年龄，初次接触的年份，接触的持续时间，潜伏期和工作类型与肺癌，胸膜和腹膜癌，石棉沉着症和间皮瘤死亡率的相对风险有关。结论：证实了石棉暴露与肺癌，腹膜和胸膜癌，间皮瘤和石棉病的死亡率之间的已知关联，并观察到与中风和胃癌死亡率相关的证据。有限的证据表明，在最近时期首次接触石棉的人患石棉的疾病风险可能较低。

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