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首页> 外文期刊>Occupational and environmental medicine >Quantitative relations between exposure to respirable quartz and risk of silicosis.
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Quantitative relations between exposure to respirable quartz and risk of silicosis.

机译：接触可吸入石英与矽肺风险之间的定量关系。

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AIMS: To reanalyse exposure-response data from a Scottish colliery to gain a more detailed knowledge of the relations between exposure to quartz and risks of silicosis in coal miners, and hence inform the debate on an appropriate occupational standard for respirable quartz. METHODS: Detailed data on working times at different quartz concentrations were combined to produce exposure profiles for miners who had provided a full chest radiograph at a follow up survey. Logistic regression methods were used to model profusion of radiographic abnormalities category 2/1+, and a general exposure index was used to compare different quartz exposure measures in these models. RESULTS: Results in 371 men aged 50-74 indicated that cumulative quartz exposure at higher concentrations resulted in proportionally greater risks of abnormalities. One g x h x m(-3) of cumulative exposure at quartz concentrations greater than 2 mg x m(-3) was estimated to have equivalent risks to 3 g x h x m(-3) at lower concentrations. The timing of exposure relative to follow up appeared less important, although the study had limited power to compare different lag periods between exposure and effect. CONCLUSIONS: Quantification of the risks of silicosis should take account of variations in quartz exposure intensity, particularly for exposure to concentrations of greater than 1 or 2 mg.m(-3), even if exposure is for relatively short periods. The risks of silicosis over a working lifetime can rise dramatically with even brief exposure to such high quartz concentrations. Risk estimates are given, to inform choice of control limits.
机译：目的：重新分析来自苏格兰煤矿的暴露响应数据，以更详细地了解石英暴露与煤矿工人矽肺病风险之间的关系，从而为有关可吸入石英的适当职业标准的辩论提供参考。方法：将在不同石英浓度下工作时间的详细数据结合起来，得出在后续调查中提供了完整胸部X光片的矿工的暴露曲线。使用逻辑回归方法对放射线异常类别2/1 +的大量进行建模，并使用一般暴露指数来比较这些模型中不同的石英暴露量度。结果：371名年龄在50-74岁之间的男性的结果表明，更高浓度的累积石英暴露会成比例地增加发生异常的风险。石英浓度大于2 mg x m（-3）时1 g x h x m（-3）的累积暴露量估计与较低浓度下3 g x h x m（-3）的风险相当。尽管该研究比较暴露和效果之间的不同滞后时间的能力有限，但相对于随访的时间安排显得不太重要。结论：硅肺病风险的量化应考虑石英暴露强度的变化，特别是对于浓度大于1或2 mg.m（-3）的暴露，即使暴露时间相对较短。即使短暂暴露于如此高的石英浓度下，矽肺病在整个工作寿命中的风险也会急剧增加。给出了风险估计，以告知控制限制的选择。

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