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首页> 外文期刊>Occupational and environmental medicine >Lung cancer mortality among chromate production workers.
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Lung cancer mortality among chromate production workers.

机译：铬酸盐生产工人的肺癌死亡率。

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AIMS: To assess mortality in 1997 among 493 former workers of a US chromate production plant employed for at least one year between 1940 and 1972. METHODS: Cohort members were followed for mortality to 31 December 1997. Standardised mortality ratios (SMRs) were calculated for selected cause specific categories of death including lung cancer. Lung cancer mortality was investigated further by calculation of SMRs stratified by year of hire, duration of employment, time since hire, and categories of cumulative exposure to Cr(VI). RESULTS: Including 51 deaths due to lung cancer, 303 deaths occurred. SMRs were significantly increased for all causes combined (SMR = 129), all cancers combined (SMR = 155), and lung cancer (SMR = 241). A trend test showed a strong relation between lung cancer mortality and cumulative hexavalent exposure. Lung cancer mortality was increased for the highest cumulative exposure categories (> or =1.05 to <2.70 mg/m(3)-years, SMR = 365; > or =2.70 to 23 mg/m(3)-years, SMR = 463), butnot for the first three exposure groups. Significantly increased SMRs were also found for year of hire before 1960, 20 or more years of exposed employment, and latency of 20 or more years. CONCLUSIONS: The finding of an increased risk of lung cancer mortality associated with Cr(VI) exposure is consistent with previous reports. Stratified analysis of lung cancer mortality by cumulative exposure suggests a possible threshold effect, as risk is significantly increased only at exposure levels over 1.05 mg/m(3)-years. Though a threshold is consistent with published toxicological evidence, this finding must be interpreted cautiously because the data are also consistent with a linear dose response.
机译：目的：为了评估1997年在美国铬酸盐生产厂的493名前工人的死亡率，该工人在1940年至1972年之间雇用了至少一年。方法：对队列成员进行随访，直至1997年12月31日。计算标准死亡率（SMR）。选择导致特定类型的死亡，包括肺癌。通过计算SMR来进一步调查肺癌死亡率，这些SMR按雇用年份，雇用期限，雇用时间，以及对Cr（VI）的累积暴露量进行分层。结果：包括51例因肺癌死亡，其中303例死亡。 SMRs在所有原因（SMR = 129），所有癌症（SMR = 155）和肺癌（SMR = 241）的综合原因下均显着增加。趋势测试显示肺癌死亡率与累积六价暴露之间有密切关系。对于最高累积暴露类别（>或= 1.05至<2.70 mg / m（3）年，SMR = 365;>或= 2.70至23 mg / m（3）年，SMR = 463，肺癌死亡率增加），但不适用于前三个暴露组。在1960年之前的雇用年，20年或20年以上的受雇工作以及20年或20年以上的潜伏期中也发现SMR显着增加。结论：与六价铬暴露相关的肺癌死亡风险增加的发现与以前的报道一致。通过累积暴露量对肺癌死亡率进行分层分析表明可能存在阈值效应，因为仅在暴露水平超过1.05 mg / m（3）-年时风险才显着增加。尽管阈值与已公布的毒理学证据一致，但是必须谨慎解释这一发现，因为数据也与线性剂量反应一致。

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