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首页> 外文期刊>Occupational and environmental medicine >Land contamination and urinary abnormalities: cause for concern?
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Land contamination and urinary abnormalities: cause for concern?

机译：土地污染和尿液异常：值得关注吗？

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摘要

AIMS: To determine the prevalence of proteinuira and enzymuria among a cohort of subjects exposed to hexachlorobutadiene (HCBD) in their homes and to determine whether there was a change in observed effects when exposure ceased. METHODS: Residents underwent a health check, which included a panel of urinary markers of both glomerular and tubular origin, within two months of cessation of long term exposure to HCBD and again at least 10 months after exposure ceased. Analysis of the results was performed to determine if there was any early evidence of renal effects, and to ascertain whether changes in these parameters occurred after exposure to HCBD ceased. RESULTS: Tubular proteinuria and enzymuria were increased in the initial health check and significantly decreased after the residents had left their homes for about 10 months. As the early renal tubular markers improved when exposure ceased it is anticipated that the long term nephrotoxic risk will be minimal, but the carcinogenic risk remains unknown. CONCLUSIONS: Results show there was a renal effect which improved when subjects left their homes. This suggests there was a local environmental factor responsible for the observations. This is consistent with the predicted toxicological effects of HCBD from animal studies.
机译：目的：确定在家庭中接触六氯丁二烯（HCBD）的一组受试者中蛋白尿和酶尿的患病率，并确定停止接触后观察到的效果是否发生变化。方法：在长期停止接触六氯丁二烯后两个月内以及停止接触后至少十个月内，对居民进行健康检查，其中包括一组肾小球和肾小管泌尿标记物。对结果进行了分析，以确定是否有任何早期的肾效应证据，并确定在停止接触六氯丁二烯后这些参数是否发生变化。结果：在最初的健康检查中，管状蛋白尿和酶尿增加，而居民离开家大约10个月后显着下降。随着停止接触后早期肾小管标志物的改善，预计长期肾毒性风险将降至最低，但致癌风险仍然未知。结论：结果显示，当受试者离开家园时，肾功能得到改善。这表明存在局部环境因素负责观测。这与动物研究预测的六氯丁二烯的毒理作用是一致的。

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