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首页> 外文期刊>Occupational and environmental medicine >Incidence of haematopoietic malignancies in US radiologic technologists.
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Incidence of haematopoietic malignancies in US radiologic technologists.

机译：美国放射技术专家的造血系统恶性肿瘤发病率。

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BACKGROUND: There are limited data on risks of haematopoietic malignancies associated with protracted low-to-moderate dose radiation. AIMS: To contribute the first incidence risk estimates for haematopoietic malignancies in relation to work history, procedures, practices, and protective measures in a large population of mostly female medical radiation workers. METHODS: The investigators followed up 71,894 (77.9% female) US radiologic technologists, first certified during 1926-80, from completion of a baseline questionnaire (1983-89) to return of a second questionnaire (1994-98), diagnosis of a first cancer, death, or 31 August 1998 (731,306 person-years), whichever occurred first. Cox proportional hazards regression was used to compute risks. RESULTS: Relative risks (RR) for leukaemias other than chronic lymphocytic leukaemia (non-CLL, 41 cases) were increased among technologists working five or more years before 1950 (RR = 6.6, 95% CI 1.0 to 41.9, based on seven cases) or holding patients 50 or more times for x ray examination (RR = 2.6, 95% CI 1.3 to 5.4). Risks of non-CLL leukaemias were not significantly related to the number of years subjects worked in more recent periods, the year or age first worked, the total years worked, specific procedures or equipment used, or personal radiotherapy. Working as a radiologic technologist was not significantly linked with risk of multiple myeloma (28 cases), non-Hodgkin's lymphoma (118 cases), Hodgkin's lymphoma (31 cases), or chronic lymphocytic leukaemia (23 cases). CONCLUSION: Similar to results for single acute dose and fractionated high dose radiation exposures, there was increased risk for non-CLL leukaemias decades after initial protracted radiation exposure that likely cumulated to low-to-moderate doses.
机译：背景：关于与长期中低剂量放射有关的造血系统恶性肿瘤风险的数据有限。目的：在大多数女性医疗放射工作人员中，提供与工作历史，程序，做法和保护措施相关的造血系统恶性肿瘤的首次发病风险估计。方法：研究人员随访了71,894名（占77.9％的女性）美国放射线技术人员，这些技术人员于1926-80年间首先获得认证，从完成基线调查表（1983-89年）到退回第二份调查表（1994-98年），并诊断出第一份癌症，死亡或1998年8月31日（731,306人年），以先到者为准。使用Cox比例风险回归来计算风险。结果：在1950年之前工作了五年或五年以上的技术人员中，慢性淋巴细胞白血病以外的白血病的相对风险（RR）（41例）增加了（基于7例，RR = 6.6，95％CI 1.0至41.9）。或让患者接受50次或更多次X射线检查（RR = 2.6，95％CI为1.3至5.4）。非CLL白血病的风险与受试者在最近时期工作的年数，首次工作的年龄或年龄，工作的总年数，使用的特定程序或设备或个人放疗的关系不大。放射技师的工作与多发性骨髓瘤（28例），非霍奇金淋巴瘤（118例），霍奇金淋巴瘤（31例）或慢性淋巴细胞性白血病（23例）的风险没有显着相关。结论：类似于单次急性剂量和分次高剂量放射线照射的结果，在最初长期持续的放射线照射后几十年内，累计至中低剂量的非CLL白血病风险增加。

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