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首页> 外文期刊>Occupational and environmental medicine >Exposure to traffic exhausts and oxidative DNA damage.
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Exposure to traffic exhausts and oxidative DNA damage.

机译：暴露于交通尾气和氧化性DNA损伤。

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AIMS: To assess the relations between exposure to traffic exhausts and indicators of oxidative DNA damage among highway toll station workers. METHODS: Cross-sectional study of 47 female highway toll station workers exposed to traffic exhausts and 27 female office workers as a reference group. Exposure assessment was based on average and cumulative traffic density and a biomarker of exposure, urinary 1-hydroxypyrene-glucuronide (1-OHPG). Urinary 8-hydroxydeoxyguanosine (8-OHdG) was used as a biomarker of oxidative DNA damage. Plasma nitric oxide (NO) was measured as an indicator of oxidative stress related to traffic exhaust exposure. RESULTS: The mean concentration of urinary 8-OHdG was substantially higher among the exposed non-smokers (13.6 microg/g creatinine) compared with the reference non-smokers (7.3 microg/g creatinine; difference 6.3, 95% CI 3.0 to 9.6). The mean concentration of NO among the exposed (48.0 micromol/l) was also higher compared with the reference non-smokers (37.6 micromol/l; difference 10.4, 95% CI -0.4 to 21.2). In linear regression adjusting for confounding, a change in log(8-OHdG) was statistically significantly related to a unit change in log(1-OHPG) (beta = 0.372, 95% CI 0.081 to 0.663). CONCLUSIONS: Results indicate that exposure to traffic exhausts increases oxidative DNA damage. Urinary 8-OHdG is a promising biomarker of traffic exhaust induced oxidative stress.
机译：目的：评估高速公路收费站工作人员暴露于交通尾气与DNA氧化损伤指标之间的关系。方法：横断面研究47名女性公路收费站工作人员暴露于交通尾气和27名女性上班族作为参考人群。暴露评估基于平均和累积交通密度以及暴露的生物标志物尿1-羟基py-葡糖醛酸（1-OHPG）。尿中的8-羟基脱氧鸟苷（8-OHdG）被用作氧化性DNA损伤的生物标记。测量血浆一氧化氮（NO）作为与交通尾气暴露相关的氧化应激指标。结果：暴露的非吸烟者尿中8-OHdG的平均浓度显着高于参考非吸烟者（7.3微克/克肌酐;差异6.3，95％CI 3.0至9.6）。 。与参考非吸烟者（37.6 micromol / l;相差10.4，95％CI -0.4至21.2）相比，暴露的NO的平均浓度（48.0 micromol / l）也更高。在进行线性回归调整以消除混淆时，log（8-OHdG）的变化与log（1-OHPG）的单位变化在统计学上显着相关（β= 0.372，95％CI 0.081至0.663）。结论：结果表明，暴露于交通尾气会增加DNA的氧化损伤。尿中的8-OHdG是一种有希望的交通标志物诱导的氧化应激生物标志物。

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