...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Occupational and environmental medicine >Occupational kidney disease among Chinese herbalists exposed to herbs containing aristolochic acids.
【24h】

Occupational kidney disease among Chinese herbalists exposed to herbs containing aristolochic acids.

机译：暴露于含有马兜铃酸的草药的中医师中的职业性肾脏疾病。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE: Many Chinese herbs contain aristolochic acids (ALAs) which are nephrotoxic and carcinogenic. The objective of this study was to identify whether exposure to herbs containing ALAs increased the risk of kidney disease among Chinese herbalists. METHODS: A nested case-control study was carried out on 6538 Chinese herbalists registered between 1985 and 1998. All incident cases of chronic renal failure reported to the Database of Catastrophic Illness of the National Health Insurance Bureau between 1995 and 2000 were defined as the case group. Up to four controls without renal failure were randomly matched to each case by sex and year of birth. A structured questionnaire survey was administered between November and December 2002. The Mantel-Haenszel method and conditional logistic regression were used to estimate the risks. RESULTS: 40 cases and 98 matched controls were included in the final analysis. After adjusting for age, frequent analgesic use, and habitual consumption of alcohol, fermented or smoked food, we found manufacturing and selling Chinese herbal medicine (OR 3.43, 95% CI 1.16 to 10.19), processing, selling or dispensing herbal medicines containing Fangji (OR 4.17, 95% CI 1.36 to 12.81), living in the workplace (OR 3.14, 95% CI 1.11 to 8.84) and a history of taking of herbal medicines containing Fangji (frequently or occasionally) (OR 5.42, 95% CI 1.18 to 24.96) were significantly associated with renal failure. CONCLUSION: Occupational exposure to and consumption of herbs containing ALAs increases the risk of renal failure in Chinese herbalists.
机译：目的：许多中草药都含有马兜铃酸（ALA），具有肾毒性和致癌性。这项研究的目的是确定暴露于含有ALA的草药是否会增加中草药医师患肾脏疾病的风险。方法：对1985年至1998年注册的6538名中医进行了巢式病例对照研究。将1995年至2000年向国家健康保险局灾难性疾病数据库报告的所有慢性肾功能衰竭病例定义为病例。组。根据性别和出生年份，将多达四个无肾功能衰竭的对照随机匹配到每个病例。在2002年11月至2002年12月之间进行了结构化问卷调查。使用了Mantel-Haenszel方法和条件逻辑回归来估计风险。结果：40例患者和98例匹配对照纳入最终分析。在调整了年龄，频繁使用止痛药以及习惯性饮酒，发酵或熏制食品后，我们发现制造和销售中草药（OR 3.43，95％CI 1.16至10.19），加工，销售或配发含方剂（或4.17，95％CI 1.36至12.81），在工作场所生活（或3.14，95％CI 1.11至8.84）以及服用方济草药的历史（频繁或偶尔）（OR 5.42，95％CI 1.18至24.96）与肾衰竭显着相关。结论：职业性接触和食用含有ALA的草药会增加中国中医师的肾衰竭风险。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号