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首页> 外文期刊>Occupational and environmental medicine >Lung cancer incidence among Norwegian silicon carbide industry workers: Associations with particulate exposure factors
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Lung cancer incidence among Norwegian silicon carbide industry workers: Associations with particulate exposure factors

机译：挪威碳化硅行业工人中的肺癌发生率：与微粒暴露因素的关联

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摘要

Objectives:An increased lung cancer risk associated with total dust exposure in the silicon carbide (SiC) industry has previously been reported. The aim of the present study was to examine the relative importance of specific exposure factors by using a comprehensive, historic job exposure matrix based on about 8000 measurements. Methods: Cumulative exposure to total and respirable dust, respirable quartz, cristobalite, and SiC particles and SiC fibres was assessed for 1687 long-term workers employed during 1913-2003 in the Norwegian SiC industry. Standardised incidence ratios for lung cancer, with follow-up during 1953-2008, were calculated stratified by cumulative exposure categories. Poisson regression analyses were performed using both categorised and log-transformed cumulative exposure variables. Results: The lung cancer incidence was about twofold increased at the highest level of exposure to each of the exposure factors (standardised incidence ratios 1.9-2.3 for all agents). Internal analyses showed associations between exposure level and lung cancer incidence for all investigated factors, but a significant trend only for total dust and cristobalite. In multivariate analyses, cristobalite showed the most consistent associations, followed by SiC fibres. Conclusions: The results indicated that crystalline silica in the form of cristobalite was the most important occupational exposure factor responsible for lung cancer excess in the Norwegian SiC industry. SiC fibres seemed to have an additional effect.
机译：目标：先前已经报道了碳化硅（SiC）行业中与总粉尘接触相关的肺癌风险增加。本研究的目的是通过使用基于大约8000个测量值的全面的历史性工作暴露矩阵来检查特定暴露因子的相对重要性。方法：评估了1913年至2003年期间在挪威SiC行业中雇用的1687名长期工人的总暴露量和可吸入粉尘，可吸入石英，方石英，SiC颗粒和SiC纤维的累积暴露。按累积的暴露类别对1953年至2008年间随访的肺癌的标准化发病率进行分层。使用分类的和对数转换的累积暴露变量进行泊松回归分析。结果：在每种暴露因子的最高暴露水平下，肺癌的发病率增加了约两倍（所有药物的标准化发病率均为1.9-2.3）。内部分析显示，在所有调查的因素中，暴露水平与肺癌发生率之间存在关联，但仅总粉尘和方石英呈显着趋势。在多变量分析中，方石英显示出最一致的缔合，其次是SiC纤维。结论：结果表明，方石英形式的结晶二氧化硅是导致挪威SiC工业中肺癌过量的最重要的职业接触因子。 SiC纤维似乎还有其他作用。

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