...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Occupational and environmental medicine >Changes in lymphocyte subsets in workers exposed to 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD)
【24h】

Changes in lymphocyte subsets in workers exposed to 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD)

机译：接触2,3,7,8-四氯二苯并-对-二恶英（TCDD）的工人中淋巴细胞亚群的变化

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objectives: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is known to have toxic effects on the haematopoietic system in animals but epidemiological studies in humans have shown inconsistent results. In this cross-sectional study we investigated changes in peripheral blood cell counts and lymphocyte subsets among workers from a Dutch historical cohort occupationally exposed to chlorophenoxy herbicides and contaminants including TCDD. Methods: Forty-seven workers who had been exposed to high levels of TCDD in the past and 38 low-exposed workers were included in the current investigation. Complete blood counts and differential and major lymphocyte subsets were analysed. Current plasma levels of TCDD (TCDD current) were determined by high-resolution gas chromatography/isotope-dilution high resolution mass spectrometry. TCDD blood levels at the time of last exposure (TCDD max) were estimated using a one-compartment first order kinetic model. Results: Cell counts and lymphocyte subsets were similar between high- and low-exposed workers, except for a non-dose dependent increase in CD4/CD8 ratio among high-exposed workers. Interestingly, most lymphocyte subsets, in particular the B cell compartment, showed a decrease with increasing levels of both TCDD current and TCDD max. Conclusions: Overall, our study showed that plasma TCDD levels had no effect on white blood cell counts and major subsets. However, a non-significant decrease in most lymphocyte subsets was noted, with the strongest effect for B cells. The latter finding may suggest that dioxin exposure might have an adverse impact on the haematopoietic system and lends some support to B cell lymphoma induction by dioxin.
机译：目的：已知2,3,7,8-四氯二苯并-对-二恶英（TCDD）对动物的造血系统具有毒性作用，但人类的流行病学研究显示结果不一致。在这项横断面研究中，我们调查了荷兰历史队列的工人的外周血细胞计数和淋巴细胞亚群的变化，这些工人职业性地接触了氯苯氧基除草剂和包括TCDD在内的污染物。方法：过去曾接触高水平TCDD的47名工人和38位低接触的工人被纳入当前调查。分析全血细胞计数以及分化和主要淋巴细胞亚群。 TCDD的当前血浆水平（TCDD电流）通过高分辨率气相色谱/同位素稀释高分辨率质谱法测定。使用单室一级动力学模型估算最后一次暴露时的TCDD血液水平（最大TCDD）。结果：高暴露工人和低暴露工人之间的细胞计数和淋巴细胞亚群相似，除了高剂量工人中CD4 / CD8比值的非剂量依赖性增加外。有趣的是，大多数淋巴细胞亚群，特别是B细胞区室，都随着TCDD current和TCDD max的升高而降低。结论：总的来说，我们的研究表明血浆TCDD水平对白细胞计数和主要亚群没有影响。但是，注意到大多数淋巴细胞亚群均无明显下降，对B细胞的作用最强。后一个发现可能表明二恶英暴露可能会对造血系统产生不利影响，并为二恶英诱导B细胞淋巴瘤提供一些支持。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号