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首页> 外文期刊>Occupational and environmental medicine >Urinary 1-hydroxypyrene in coke oven workers relative to exposure, alcohol consumption, and metabolic enzymes.
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Urinary 1-hydroxypyrene in coke oven workers relative to exposure, alcohol consumption, and metabolic enzymes.

机译：与暴露，酒精消耗和代谢酶有关的炼焦炉工人尿中的1-羟基py。

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OBJECTIVES: To investigate the influence of personal lifestyle--such as smoking and alcohol consumption-on urinary 1-hydroxypyrene (1-OHP) concentrations in coke oven workers exposed to polycyclic aromatic hydrocarbons (PAHs) and to evaluate the association of 1-OHP concentrations with the genetic polymorphism of several metabolic enzymes including cytochrome P-450 (CYP) 1A1 and glutathione S-tranferases (GSTs). METHODS: The study population contained 162 coke oven workers and 58 controls employed at the largest iron and steel factory in China. Personal data were collected at the interview. 1-OHP in urine was measured with high performance liquid chromatography with fluorescence detection. Genetic polymorphisms were identified by the polymerase chain reaction (PCR) method. RESULTS: A positive association between excretion of urinary 1-OHP and the levels of exposure to PAHs was confirmed. Those people who consumed >or=50 g/day ethanol had significantly higher 1-OHP excretion than did other coke oven workers (p<0.01). No significant difference in urinary 1-OHP was found between smokers and non-smokers, in both controls and exposed subjects. The variant homozygotes at exon 7 of the CYP1A1 gene had significantly higher urinary 1-OHP concentrations than other CYP1A1 genotypes among the exposed workers (p=0.03). There was less association between the concentrations of 1-OHP and the GSTM1, GSTP1, or GSTT1 polymorphism. CONCLUSIONS: The present study confirmed that urinary 1-OHP is a good biomarker for exposure to PAHs. Alcohol consumption affected urinary 1-OHP excretion. The variant genotypes of the CYP1A1 gene may result in the enhancement of PAH metabolites. It is helpful to understand the role of individual susceptibility on metabolism of carcinogens. These findings suggest that the modulating effect of individual lifestyle factors or genetic nature should be considered in future studies on occupational exposure to PAHs and in evaluating the health risk from harmful chemicals.
机译：目的：研究个人生活方式（如吸烟和饮酒）对暴露于多环芳烃（PAHs）的炼焦炉工人尿中1-羟基py（1-OHP）浓度的影响，并评估1-OHP的相关性浓度与几种代谢酶的遗传多态性有关，包括细胞色素P-450（CYP）1A1和谷胱甘肽S-转移酶（GST）。方法：研究人群包括中国最大的钢铁厂雇用的162名炼焦炉工人和58名控制人员。面试时收集了个人数据。尿液中的1-OHP用高效液相色谱-荧光检测法测定。遗传多态性通过聚合酶链反应（PCR）方法鉴定。结果：尿1-OHP的排泄与PAHs暴露水平之间呈正相关。那些每天摄入大于或等于50克乙醇的人的1-OHP排泄量明显高于其他炼焦炉工人（p <0.01）。在对照组和暴露受试者中，吸烟者和不吸烟者之间尿中1-OHP含量均无显着差异。在暴露的工人中，CYP1A1基因第7外显子的纯合子尿1-OHP浓度明显高于其他CYP1A1基因型（p = 0.03）。 1-OHP浓度与GSTM1，GSTP1或GSTT1多态性之间的关联较少。结论：本研究证实尿中1-OHP是暴露于PAHs的良好生物标志物。饮酒会影响尿中1-OHP的排泄。 CYP1A1基因的变异基因型可能导致PAH代谢产物的增强。了解个体易感性对致癌物代谢的作用是有帮助的。这些发现表明，在以后的职业暴露于多环芳烃的研究以及评估有害化学物质对健康的风险中，应考虑个体生活方式因素或遗传性质的调节作用。

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