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首页> 外文期刊>Occupational and environmental medicine >Incidence of childhood brain and other non-haematopoietic neoplasms near nuclear sites in Scotland, 1975-94.
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Incidence of childhood brain and other non-haematopoietic neoplasms near nuclear sites in Scotland, 1975-94.

机译：1975-94年，苏格兰核地区附近的儿童大脑和其他非造血肿瘤发病率。

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OBJECTIVES: To examine the risk of cancers other than leukaemia and non-Hodgkin's lymphoma in children resident in the vicinity of nuclear sites in Scotland. METHODS: The study dataset comprised registrations of cancer other than leukaemia and non-Hodgkin's lymphoma diagnosed in children aged under 15 in the period 1975-94. These were validated for completeness and accuracy and analysed in two groups: (a) tumours of the central nervous system and (b) other malignant tumours (excluding leukaemia and non-Hodgkin's lymphoma). Around each nuclear site observed cases (O) were enumerated and expected numbers (E) calculated with adjustment for age, sex, deprivation, and an urban-rural category. Stone's maximum likelihood ratio test (MLR) was used to determine whether there was any evidence of increased risk of these neoplasms among children living within 25 km of one of the nuclear sites investigated. The significance level of each MLR statistic was estimated by simulation. RESULTS: More tumours of the central nervous system were observed than expected within 25 km of Dounreay (O/E = 1.14), Hunterston (1.14), and Rosyth (1.22). These results were based on 2, 26, and 136 observed cases, respectively. The unconditional MLR was significant only for Rosyth (p = 0.006). The conditional application of the MLR test for Rosyth was not significant (p = 0.771). For the group of other malignant neoplasms, the unconditional MLR test was not significant for any of the seven sites. CONCLUSIONS: There was no evidence for generally increased risk of either tumours of the central nervous system or other malignant tumours in children living near nuclear sites. The significant excess of tumours of the central nervous system around Rosyth is likely to be due to the high incidence of these tumours in east central Scotland. Further investigations in this area are warranted.
机译：目的：检查居住在苏格兰核电站附近儿童中除白血病和非霍奇金淋巴瘤以外的癌症的风险。方法：该研究数据集包括在1975-94年期间诊断为15岁以下儿童的白血病和非霍奇金淋巴瘤以外的癌症。已对它们的完整性和准确性进行了验证，并分为两组：（a）中枢神经系统肿瘤和（b）其他恶性肿瘤（不包括白血病和非霍奇金淋巴瘤）。在每个核电站周围，列举了观察到的病例（O），并根据年龄，性别，贫困和城乡类别对预期病例数（E）进行了计算。使用斯通的最大似然比检验（MLR）来确定是否有证据表明生活在所调查的核站点之一25公里以内的儿童中这些肿瘤的风险增加。每个MLR统计量的显着性水平通过仿真估算。结果：在Dounreay（O / E = 1.14），Hunterston（1.14）和Rosyth（1.22）的25公里内，观察到的中枢神经系统肿瘤多于预期。这些结果分别基于观察到的2、26和136个案例。无条件MLR仅对Rosyth有意义（p = 0.006）。 MLR测试对Rosyth的有条件应用并不显着（p = 0.771）。对于其他恶性肿瘤，这七个部位中的任何部位的无条件MLR试验均不显着。结论：没有证据表明居住在核位点附近的儿童中枢神经系统肿瘤或其他恶性肿瘤的风险普遍增加。 Rosyth周围中枢神经系统的肿瘤过多，可能是由于苏格兰东部中部这些肿瘤的高发率所致。有必要在此领域进行进一步调查。

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