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Exposure to chlorinated solvents and lung cancer: Results of the ICARE study

机译：暴露于氯化溶剂和肺癌：ICARE研究的结果

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ICARE (Investigation of occupational and environmental CAuses of REspiratory cancers), a French, multicenter, population-based, case-control study, is conducted to investigate the role of occupational exposure to chlorinated solvents in lung cancer etiology. Information on the lifelong work history of 2,926 cases and 3555 controls was collected using standardized questionnaires. Occupational exposures were assessed using job-exposure matrices for five chlorinated solvents, namely, trichloroethylene (TCE), dichloromethyane (DCM), perchloroethylene (PCE), chloroform (CF), and carbon tetrachloride (CT). Solvents were studied separately and in combinations. After adjustment for exposure to asbestos, we, a positive, statistically significant association with lung cancer for men and women exposed to a combination of PCE, TCE, and DCM was observed. Further adjustment for SES slightly decreased this association, while no statistically significant associations were found for other solvent combinations. These results suggest that exposure to PCE may constitute a risk factor for lung cancer, especially among women, who seem to have a higher prevalence of exposure than men.
机译：一项基于人口的法国，多中心，病例对照研究ICARE（呼吸道癌的职业和环境原因调查）旨在调查职业性接触氯化溶剂在肺癌病因中的作用。使用标准化问卷收集了有关2926例病例和3555例对照的终生工作史的信息。使用五种氯化溶剂的工作暴露矩阵评估了职业暴露，即三氯乙烯（TCE），二氯甲烷（DCM），四氯乙烯（PCE），氯仿（CF）和四氯化碳（CT）。分别或组合研究了溶剂。调整石棉暴露量后，我们发现，暴露于PCE，TCE和DCM组合的男性和女性与肺癌呈统计学意义的正相关。对SES的进一步调整稍微降低了这种关联，而对于其他溶剂组合，没有发现统计学上显着的关联。这些结果表明，暴露于PCE可能是肺癌的危险因素，尤其是在女性中，她们的暴露患病率似乎比男性高。

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