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首页> 外文期刊>Occupational and environmental medicine >Epidemiological survey of workers exposed to inorganic germanium compounds.
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Epidemiological survey of workers exposed to inorganic germanium compounds.

机译：接触无机锗化合物的工人的流行病学调查。

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OBJECTIVES: To assess occupational exposure to inorganic germanium (Ge) in workers from a producing plant, and to assess the health of these workers, with a special focus on respiratory, kidney, and liver functions. METHODS: Cross sectional study of 75 workers exposed to Ge and 79 matched referents. Exposure was characterised by measuring air and urine concentrations of the element during a typical working week, and health was assessed by a questionnaire, clinical examination, lung function testing, chest radiography, and clinical chemistry in serum and urine, including high and low molecular weight urinary proteins. RESULTS: Airborne concentrations of Ge (inhalable fraction) ranged from 0.03 to 300 micrograms/m, which was reflected by increased urinary excretion of Ge (0.12-200 micrograms/g creatinine, after the shift at the end of the working week). Lung, liver, and haematological variables were not significantly different between referents and workers exposed to Ge. A slightly higher urinary concentration of high molecular weight proteins (albumin and transferrin) was found in workers exposed to Ge, possibly reflecting subclinical glomerular changes. No relation was found between the intensity or duration of exposure and the urinary concentration of albumin. No difference between referents and workers exposed to Ge was found for other renal variables. CONCLUSIONS: Measurement of urinary Ge can detect occupational exposure to inorganic Ge and its compounds. It is prudent to recommend the monitoring of renal variables in workers exposed to Ge.
机译：目的：评估某生产工厂工人的职业接触无机锗（Ge）的情况，并评估这些工人的健康状况，并特别关注呼吸，肾脏和肝脏功能。方法：对75名接触Ge的工人和79名匹配对象进行了横断面研究。通过在典型的工作周内测量空气和尿液中元素的浓度来表征暴露，并通过问卷，临床检查，肺功能测试，胸部放射线检查以及血清和尿液中的化学成分（包括高和低分子量）评估健康状况尿蛋白。结果：空气中Ge的浓度（可吸入部分）在0.03至300微克/米之间，这反映为Ge的尿排泄增加（工作周结束后，尿的排泄量为0.12-200微克/克肌酐）。接触对象和接触Ge的工人之间的肺，肝和血液学变量无显着差异。在接触Ge的工人中发现高分子量蛋白（白蛋白和转铁蛋白）的尿液浓度略高，这可能反映了亚临床肾小球的变化。在暴露的强度或持续时间与白蛋白的尿液浓度之间没有关系。在其他肾脏变量中，未发现被访者和接触Ge的工人之间没有差异。结论：尿锗的测量可以检测出无机锗及其化合物的职业暴露。建议谨慎监测暴露于Ge的工人的肾脏变量。

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