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首页> 外文期刊>Occupational and environmental medicine >Association between exhaled breath condensate nitrate + nitrite levels with ambient coarse particle exposure in subjects with airways disease
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Association between exhaled breath condensate nitrate + nitrite levels with ambient coarse particle exposure in subjects with airways disease

机译：呼吸道疾病患者呼出气冷凝物硝酸盐+亚硝酸盐水平与周围粗颗粒暴露之间的关系

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Objectives: Studies of individual inflammatory responses to exposure to air pollution are few but are important in defining the most sensitive markers in better understanding pathophysiological pathways in the lung. The goal of this study was to assess whether exposure to airborne particles is associated with oxidative stress in an epidemiological setting. Methods: The authors assessed exposure to particulate matter air pollution in four European cities in relation to levels of nitrite plus nitrate (NOx) in exhaled breath condensate (EBC) measurements in 133 subjects with asthma or chronic obstructive pulmonary disease using an EBC capture method developed for field use. In each subject, three measurements were collected. Exposure measurements included particles smaller than 10 μm (PM 10), smaller than 2.5 μm (PM 2.5) and particle number counts at a central site, outdoors near the subject's home and indoors. Results: There were positive and significant relationships between EBC NOx and coarse particles at the central sampling sites (increase of 20.4% (95% CI 6.1% to 36.6%) per 10 μg/m 3 increase of coarse particles of the previous day) but not between EBC NOx and other particle measures. Associations tended to be stronger in subjects not taking steroid medication. Conclusions: An association was found between exposure to ambient coarse particles at central sites and EBC NOx, a marker of oxidative stress. The lack of association between PM measures more indicative of personal exposures (particularly indoor exposure) means interpretation should be cautious. However, EBC NOx may prove to be a marker of PM-induced oxidative stress in epidemiological studies.
机译：目的：对暴露于空气污染的个体炎症反应的研究很少，但对于定义最敏感的标志物以更好地了解肺的病理生理学途径至关重要。这项研究的目的是评估在流行病学背景下暴露于空气中的颗粒物是否与氧化应激有关。方法：作者使用开发的EBC捕获方法，评估了133个哮喘或慢性阻塞性肺病患者的四个欧洲城市中与亚硝酸盐和硝酸盐（NOx）的呼出气冷凝物（EBC）测量水平相关的颗粒物空气污染暴露量供现场使用。在每个受试者中，收集了三个测量值。曝光测量包括小于10μm（PM 10），小于2.5μm（PM 2.5）的颗粒以及中心位置，对象附近的室外和室内的颗粒数。结果：中央采样点的EBC NOx与粗颗粒之间存在显着正相关（前一天每增加10μg/ m 3粗颗粒增加20.4％（95％CI 6.1％至36.6％）），但不在EBC NOx和其他颗粒物措施之间。不服用类固醇药物的受试者的联想往往更强。结论：在中心部位暴露于周围的粗颗粒与氧化应激的标志物EBC NOx之间存在关联。 PM措施之间缺乏关联，更表明个人接触（尤其是室内接触）意味着解释应谨慎。然而，在流行病学研究中，EBC NOx可能被证明是PM诱导的氧化应激的标志。

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