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首页> 外文期刊>Occupational and environmental medicine >Occupational exposures and risk of stomach cancer by histological type
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Occupational exposures and risk of stomach cancer by histological type

机译：按组织学类型分的职业接触和胃癌风险

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Objective: To explore the relationship between stomach cancer (SC), by histological type, and occupations and occupational exposures. Methods: The authors conducted a hospital-based case - control study in south-east Spain. Subjects were 399 incident histological confirmed SC cases (241 intestinal and 109 diffuse adenocarcinomas) and 455 controls frequency matched by sex, age and province of residence. Occupation was coded according to the Spanish National Classification of Occupations 1994. Occupational exposures were assessed by the FINJEM Job Exposure Matrix. ORs were estimated by unconditional logistic regression adjusting for matching variables and education, smoking, alcohol and diet. Results: In men, statistically significant increased risk of the diffuse subtype was found for 'cooks' (OR 8.02), 'wood-processing-plant operators' (OR 8.13) and 'food and related products machine operators' (OR 5.40); for the intestinal subtype, a borderline association was found for 'miners and quarry workers' (OR men 4.22, 95% CI 0.80 to 22.14). Significant increased risk was observed between the diffuse subtype of SC and the highest level of exposure to 'pesticides' (ORH both sexes 10.39, 95% CI 2.51 to 43.02, p trend=0. 02) and between the intestinal subtype and asbestos (ORH men 3.71, 95% CI 1.40 to 9.83, p trend=0.07). Restricted analyses of exposures of 15 years and longer showed significant associations between the diffuse subtype and the exposure to 'wood dust' (OR men 3.05). Conclusions: This study supports the relationship previously suggested between SC and occupational exposure to dusty and high temperature environments. Several occupations may also increase the risk of diffuse SC but not the intestinal subtype.
机译：目的：按组织学类型探讨胃癌（SC）与职业和职业暴露之间的关系。方法：作者在西班牙东南部进行了一项基于医院的病例对照研究。受试者为399例经组织学确诊的SC病例（241例肠道和109例弥漫性腺癌）和455例对照频率，与性别，年龄和居住省份相匹配。根据1994年西班牙国家职业分类对职业进行编码。职业暴露由FINJEM工作暴露矩阵评估。 OR值是通过无条件logistic回归调整匹配变量和教育程度，吸烟，饮酒和饮食来估计的。结果：在男性中，发现“厨师”（OR 8.02），“木材加工厂操作员”（OR 8.13）和“食品及相关产品机器操作员”（OR 5.40）的弥漫性亚型风险在统计学上显着增加;对于肠道亚型，发现了“矿工和采石场工人”的边界线关联（OR男子为4.22，95％CI为0.80至22.14）。在SC的弥散亚型和“杀虫剂”的最高暴露水平之间（ORH，男女为10.39，95％CI为2.51至43.02，p趋势= 0.02），以及在肠道亚型和石棉之间（ORH），风险显着增加。男性3.71，95％CI为1.40至9.83，p趋势= 0.07）。对15年或更长时间的暴露进行的限制性分析表明，弥散亚型与“木屑”暴露之间存在显着关联（OR值为3.05）。结论：这项研究支持了先前建议的SC与多尘和高温环境下的职业暴露之间的关系。某些职业也可能增加弥散性SC的风险，但不会增加肠道亚型。

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