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首页> 外文期刊>Occupational and environmental medicine >Effect of exposure to p,p'-DDE on male hormone profile in Mexican flower growers.
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Effect of exposure to p,p'-DDE on male hormone profile in Mexican flower growers.

机译：暴露于p，p'-DDE对墨西哥花卉种植者的雄性激素谱的影响。

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OBJECTIVES: p,p'-Dichlorodiphenyldichloroethene (p,p'-DDE) acts as an androgen receptor antagonist, however data regarding its hormonal effects in men are limited. The objective of this study was to evaluate the association between serum levels of p,p'-DDE and reproductive hormone profile in Mexican male flower growers. METHODS: A longitudinal study was carried out in a population of men working in the production of flowers and ornamental plants in two Mexican states during July-October 2004 (rainy season) and December 2004-May 2005 (dry season). A questionnaire including information on socioeconomic characteristics, tobacco and alcohol use, presence of chronic and acute diseases, occupational history and anthropometry was used and blood and urine samples were obtained. Serum levels of p,p'-DDE were analysed by gas chromatography; FSH, LH, testosterone, oestradiol, inhibin B and prolactin levels were measured by enzymatic immunoassay. Urinary levels of dialkylphosphates (DAPs) were analysed by gas chromatography. Associations between serum levels of p,p'-DDE and male reproductive hormones (both transformed to their natural logarithm) were evaluated using multivariate generalised estimating equation (GEE) models. RESULTS: Median p,p'-DDE levels were 677.2 ng/g lipid (range 9.4-12 696.5) during the rainy season and 626.7 ng/g lipid (range 9.4-13 668.1) during the dry season. After adjusting for potential confounders (age, body mass index, state of residence and DAPs), p,p'-DDE levels were negatively associated with prolactin (beta=-0.04; 95% CI -0.07 to -0.008) and testosterone (beta=0.04; 95% CI -0.08 to 0.005) and positively with inhibin B (beta=0.11; 95% CI 0.02 to 0.21). CONCLUSION: These results indicate that p,p'-DDE can affect hypothalamic-pituitary-gonadal axis function in humans.
机译：目的：p，p'-二氯二苯基二氯乙烯（p，p'-DDE）可作为雄激素受体拮抗剂，但有关其对男性荷尔蒙作用的数据有限。这项研究的目的是评估墨西哥雄性花农的血清p，p'-DDE水平与生殖激素谱之间的关系。方法：在墨西哥两个州的2004年7月至10月（雨季）和2004年12月至2005年5月（旱季），对从事花卉和观赏植物生产工作的男性人群进行了纵向研究。调查问卷包括社会经济特征，烟草和酒精使用，慢性和急性疾病的存在，职业病史和人体测量学信息，并获得了血液和尿液样本。通过气相色谱分析血清中的p，p'-DDE水平。 FSH，LH，睾丸激素，雌二醇，抑制素B和催乳素水平通过酶免疫法测定。通过气相色谱分析尿中磷酸二烷基酯（DAPs）的水平。使用多元广义估计方程（GEE）模型评估了血清中p，p'-DDE与男性生殖激素（均转化为自然对数）之间的关联。结果：在雨季，p，p'-DDE的中位数为677.2 ng / g脂质（9.4-12 696.5），而在旱季为626.7 ng / g脂质（9.4-13 668.1）。在调整了可能的混杂因素（年龄，体重指数，居住状态和DAP）后，p，p'-DDE水平与催乳素（β= -0.04; 95％CI -0.07至-0.008）和睾丸激素（β = 0.04; 95％CI -0.08至0.005），抑制素B阳性（β= 0.11; 95％CI 0.02至0.21）。结论：这些结果表明，p，p'-DDE可影响人类的下丘脑-垂体-性腺轴功能。

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