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首页> 外文期刊>Obstetrics and Gynecology: Journal of the American College of Obstetricians and Gynecologists >Meta-analysis of estrogen therapy in the management of urogenital atrophy in postmenopausal women: second report of the Hormones and Urogenital Therapy Committee.
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Meta-analysis of estrogen therapy in the management of urogenital atrophy in postmenopausal women: second report of the Hormones and Urogenital Therapy Committee.

机译：绝经后妇女泌尿生殖器萎缩处理中雌激素治疗的荟萃分析：激素和泌尿生殖治疗委员会的第二次报告。

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OBJECTIVE: To evaluate the efficacy of estrogen therapy in the treatment of postmenopausal women with symptoms and signs associated with urogenital atrophy, by meta-analysis of available data. METHODS: We searched the literature (Excerpta Medica, Biosis, MEDLINE, and hand search) for studies published between January 1969 and April 1995. Criteria for inclusion were English-language articles, peer-reviewed original publications, and urogenital atrophy assessed by at least one of the following outcomes: patient symptoms, physician report, pH, or cytologic change. Data had to allow comparison between treated and control groups in controlled trials or an estimated change from baseline in uncontrolled series. Meta-analytic methods were applied separately to controlled clinical trials and uncontrolled studies. RESULTS: Of the 77 relevant articles reviewed, nine contained ten randomized controlled trials. Meta-analysis of these using the Stouffer method revealed a statistically significant benefit of estrogen therapy for all outcomes studied. In 54 uncontrolled case series, the patient symptoms were treated by 24 different treatment modalities. All routes of administration appeared to be effective and maximum benefit was obtained between 1 and 3 months after the start of treatment. As expected, the least systemic absorption of estrogen was seen with estriol (administered orally or vaginally), then vaginal estradiol as measured by pretherapy and posttherapy serum estradiol and estrone. CONCLUSION: Estrogen is efficacious in the treatment of urogenital atrophy and low-dose vaginal estradiol preparations are as effective as systemic estrogen therapy in the treatment of urogenital atrophy in postmenopausal women.
机译：目的：通过对现有数据的荟萃分析，评估雌激素疗法在绝经后妇女中出现的与泌尿生殖器萎缩相关的症状和体征的疗效。方法：我们检索了文献（Excerpta Medica，Biosis，MEDLINE和人工搜集），以研究1969年1月至1995年4月之间发表的研究。纳入标准包括英语文章，经过同行评审的原始出版物和至少经评估的泌尿生殖器萎缩以下结果之一：患者症状，医生报告，pH或细胞学改变。数据必须允许对照试验中治疗组和对照组之间的比较，或者非对照系列中基线的估计变化。荟萃分析方法分别应用于对照临床试验和非对照研究。结果：在所审查的77篇相关文章中，有9篇包含十项随机对照试验。使用Stouffer方法进行的荟萃分析显示，对于所有研究的结果，雌激素治疗均具有统计学上的显着优势。在54个不受控制的病例系列中，通过24种不同的治疗方式治疗了患者的症状。在开始治疗后的1至3个月内，所有给药途径似乎都是有效的，并获得了最大的收益。如预期的那样，雌三醇的全身吸收最小（口服或阴道给药），然后通过治疗前和治疗后的血清雌二醇和雌酮测定阴道雌二醇。结论：雌激素可有效治疗泌尿生殖器萎缩，低剂量的阴道雌二醇制剂在治疗绝经后妇女泌尿生殖器萎缩方面与全身雌激素疗法一样有效。

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