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首页> 外文期刊>Revue de Medecine Veterinaire >Control of pig vaccine safety trought adjuvant design and vaccination protocol: example of a divalent Pasteurella multocida toxin and Bordetella bronchiseptica vaccine
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Control of pig vaccine safety trought adjuvant design and vaccination protocol: example of a divalent Pasteurella multocida toxin and Bordetella bronchiseptica vaccine

机译：猪疫苗安全性佐剂设计和疫苗接种方案的控制：二价多杀性巴氏杆菌毒素和支气管败血波氏杆菌疫苗的实例

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Vaccination may induce adverse effects in pigs. These effects may be general and/or local, and may have a negative impact on the herd performance and the meat quality. For optimal safety and efficacy of the vaccine, several parameters should be controlled. This article reports the findings of a study in pigs comparing different adjuvants for optimal vaccine safety. The study also allowed the comparison of vaccine protocols with either one or two intramuscular injections. Two adjuvants were studied, Montanide TM ISA 563 VG and Montanide TM IMS 251 C VG and compared to a classical formulation based on Tween/Span O/W emulsion. A commercially available Tween/Span W/O formulation served as positive control, while a non-adju-vanted vaccine was used as a negative control. The immune response to the antigens (Pasteurella multocida anatoxins (PMT) and bacterial cell wall of Bordetella bronchiseptica) was measured by antigen-specific ELISA on days 0, 42 and 113. After each injection, the general status, behaviour and body temperature of the pigs were recorded. The injection site was dissected after slaughter in order to check for local tissue reaction in the muscles. No change of behaviour was detected during the trial. Some animals showed transitory pyrexia, mainly those that had received the water-based vaccines. Strong local reactions were found in the tissues with both Tween/Span formulations. The Montanide TM IMS 251 C VG adjuvant induced the strongest immune response, but was linked to pyrexia. The results indicate that it is possible to modulate the vaccine safety through adjuvant selection. However, the adjuvant should be selected according to the intrinsic reacto-genicity of the antigenic medium.
机译：接种疫苗可能会对猪产生不良影响。这些影响可能是普遍的和/或局部的，并且可能对畜群性能和肉质产生负面影响。为了获得最佳的疫苗安全性和有效性，应控制几个参数。本文报告了一项研究结果，该研究比较了不同佐剂在猪中的最佳疫苗安全性。该研究还允许比较一种或两种肌肉注射的疫苗方案。研究了两种佐剂，Montanide TM ISA 563 VG和Montanide TM IMS 251 C VG，并与基于Tween / Span O / W乳液的经典配方进行了比较。市售Tween / Span W / O制剂用作阳性对照，而非佐剂疫苗用作阴性对照。在第0、42和113天通过抗原特异性ELISA测量对抗原（多杀巴斯德氏菌Anatoxins（PMT）和支气管博德氏杆菌细菌细胞壁）的免疫应答。每次注射后，应检查其总体状态，行为和体温。记录猪。屠宰后解剖注射部位，以检查肌肉中的局部组织反应。在试验期间未发现行为改变。一些动物表现出暂时性发热，主要是那些已经接受过水基疫苗的动物。两种吐温/跨度配方均在组织中发现强烈的局部反应。 Montanide TM IMS 251 C VG佐剂可诱导最强的免疫反应，但与发热有关。结果表明可以通过佐剂选择来调节疫苗的安全性。但是，佐剂应根据抗原性培养基的固有反应原性进行选择。

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