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首页> 外文期刊>Cell death and differentiation >Cell death by autophagy: facts and apparent artefacts.
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Cell death by autophagy: facts and apparent artefacts.

机译：自噬引起的细胞死亡：事实和明显的假象。

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Autophagy (the process of self-digestion by a cell through the action of enzymes originating within the lysosome of the same cell) is a catabolic process that is generally used by the cell as a mechanism for quality control and survival under nutrient stress conditions. As autophagy is often induced under conditions of stress that could also lead to cell death, there has been a propagation of the idea that autophagy can act as a cell death mechanism. Although there is growing evidence of cell death by autophagy, this type of cell death, often called autophagic cell death, remains poorly defined and somewhat controversial. Merely the presence of autophagic markers in a cell undergoing death does not necessarily equate to autophagic cell death. Nevertheless, studies involving genetic manipulation of autophagy in physiological settings provide evidence for a direct role of autophagy in specific scenarios. This article endeavours to summarise these physiological studies where autophagy has a clear role in mediating the death process and discusses the potential significance of cell death by autophagy.
机译：自噬（细胞通过同一细胞的溶酶体中的酶的作用自我消化的过程）是分解代谢过程，通常被细胞用作营养控制条件下质量控制和存活的机制。由于自噬通常是在可能导致细胞死亡的应激条件下诱导的，因此，自噬可以作为细胞死亡机制的想法已经广为传播。尽管越来越多的证据表明细胞通过自噬而死亡，但是这种类型的细胞死亡（通常称为自噬细胞死亡）仍然定义不清，有些争议。仅在经历死亡的细胞中自噬标记物的存在不一定等同于自噬细胞死亡。然而，涉及自噬在生理环境中的基因操纵的研究为自噬在特定情况下的直接作用提供了证据。本文致力于总结这些自噬在介导死亡过程中具有明显作用的生理研究，并讨论自噬对细胞死亡的潜在意义。

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