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首页> 外文期刊>Revue de Medecine Veterinaire >Histopathological and immunohistological findings in canine parvoviral infection: diagnosis application
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Histopathological and immunohistological findings in canine parvoviral infection: diagnosis application

机译：犬细小病毒感染的组织病理学和免疫组织学发现：诊断应用

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摘要

In this study, 10 dog puppies, 2 - 12 months old, from different breeds, were used for the comparative evaluation of histopathological findings observed in canine parvoviral infection with immunohistological detection of parvovirus antigens. Dogs exhibited diarrhoea, vomiting and cachexia and after necropsy and histopathological examination, severe enteritis (catarrhal enteritis in 8 cases, haemorrhagic and fibrinous enteritis in 2 cases) was evidenced. Although the intra-nuclear inclusion bodies, pathognomonic of the parvoviral infection, were not observed, some other characteristic signs such as villus atrophy and/or necrosis of the Payer's patches or fibrinous / haemorrhagic enteritis at a lesser extend, were found in 6 cases. The immunohistological detection of viral antigens was also positive for a total of 6 puppies in jejunum / ileum / mesenteric lymph nodes (6 cases), in adrenal glands (3 cases) and also in lungs (1 case). Nevertheless, animals (n = 2) with haemorrhagic and fibrinous enteritis were found negative whereas 2 dogs displaying none of the above histopathological mentioned signs were found positive. These results indicate that in the absence of the pathognomonic sign of the disease, characteristic histopathological signs may notalways allow diagnosis and that immunohistochemistry may enhance the diagnosis value.
机译：在这项研究中，使用10头来自不同品种的2-12个月大的幼犬，通过细小病毒抗原的免疫组织学检测，对犬细小病毒感染中观察到的组织病理学发现进行了比较评估。犬表现出腹泻，呕吐和恶病质，并且在尸检和组织病理学检查后，发现严重的肠炎（卡他性肠炎8例，出血性和纤维化肠炎2例）。尽管未观察到细小病毒感染的核内包涵体，但在6例患者中发现了一些其他特征性症状，例如绒毛萎缩和/或Payer斑块坏死或纤维/出血性肠炎。空肠/回肠/肠系膜淋巴结（6例），肾上腺（3例）和肺部（1例）的6只幼犬的病毒抗原的免疫组织学检测也呈阳性。但是，发现出血性和纤维性肠炎的动物（n = 2）为阴性，而没有显示出上述组织病理学提到的体征的2只狗为阳性。这些结果表明，在没有疾病的病理标志的情况下，典型的组织病理学标志可能始终无法进行诊断，而免疫组化可以提高诊断价值。

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