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Synthesis and characterization of electroactive and biodegradable ABA block copolymer of polylactide and aniline pentamer

机译：聚丙交酯和苯胺五聚体的电活性和可生物降解的ABA嵌段共聚物的合成与表征

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摘要

A triblock copolymer PLA-b-AP-b-PLA (PAP) of polylactide (PLA) and aniline pentamer (AP) with the unique properties of being both electroactive and biodegradable is synthesized by coupling an electroactive carboxyl-capped AP with two biodegradable bihydroxyl-capped PLAs via a condensation reaction. Three different molecule weight PAP copolymers are prepared. The PAP copolymers exhibit excellent electroactivity similar to the AP and polyaniline, which may stimulate cell proliferation and differentiation. The electrical conductivity of the PAP2 copolymer film (similar to 5 x 10(-6) S/cm) is in the semiconducting region. Transmission electron microscopic results suggest that there is microphase separation of the two block segments in the copolymer, which might contribute to the observed conductivity. The biodegradation and biocompatibility experiments in vitro prove the copolymer is biodegradable and biocompatible. Moreover, these new block copolymer shows good solubility in common organic solvents, leading to the system with excellent processibility. These biodegradable PAP copolymers with electroactive function thus possess the properties that would be potentially used as scaffold materials for neuronal or cardiovascular tissue engineering. (c) 2006 Elsevier Ltd. All rights reserved.
机译：聚丙交酯（PLA）和苯胺五聚体（AP）的三嵌段共聚物PLA-b-AP-b-PLA（PAP）具有电活性和可生物降解的独特特性，是通过将电活性羧基封端的AP与两个可生物降解的双羟基偶联而合成的通过缩合反应封端的PLA。制备了三种不同分子量的PAP共聚物。 PAP共聚物具有与AP和聚苯胺相似的优异电活性，可刺激细胞增殖和分化。 PAP2共聚物薄膜的电导率（类似于5 x 10（-6）S / cm）在半导体区域。透射电子显微镜结果表明，共聚物中两个嵌段链段存在微相分离，这可能有助于观察到的电导率。体外生物降解和生物相容性实验证明该共聚物具有生物降解性和生物相容性。此外，这些新型嵌段共聚物在普通有机溶剂中显示出良好的溶解性，从而使系统具有出色的可加工性。这些具有电活性功能的可生物降解的PAP共聚物因此具有可以用作神经元或心血管组织工程支架材料的特性。 （c）2006 Elsevier Ltd.保留所有权利。

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