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首页> 外文期刊>Biomaterials >Hydrolytic degradation and protein release studies of thermogelling polyurethane copolymers consisting of poly((R)-3-hydroxybutyrate), poly(ethylene glycol), and poly(propylene glycol).
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Hydrolytic degradation and protein release studies of thermogelling polyurethane copolymers consisting of poly((R)-3-hydroxybutyrate), poly(ethylene glycol), and poly(propylene glycol).

机译：由聚（R）-3-羟基丁酸酯，聚乙二醇和聚丙二醇组成的热凝胶聚氨酯共聚物的水解降解和蛋白质释放研究。

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This paper reports the hydrolytic degradation and protein release studies for a series of newly synthesized thermogelling tri-component multi-block poly(ether ester urethane)s consisting of poly[(R)-3-hydroxybutyrate] (PHB), poly(propylene glycol) (PPG), and poly(ethylene glycol) (PEG). The poly(PEG/PPG/PHB urethane) copolymer hydrogels were hydrolytically degraded in phosphate buffer at pH 7.4 and 37 degrees C for a period of up to 6 months. The mass loss profiles of the copolymer hydrogels were obtained. The hydrogel residues at different time periods of hydrolysis were visualized by scanning electron microscopy, which exhibited increasing porosity with time of hydrolysis. The degradation products in the buffer were characterized by GPC, (1)H NMR, MALDI-TOF, and TGA. The results showed that the ester backbone bonds of the PHB segments were broken by random chain scission, resulting in a decrease in the molecular weight. In addition, the constituents of degradation products were found to be 3-hydroxybutyric acid monomer and oligomers of various lengths (n=1-5). The protein release profiles of the copolymer hydrogels were obtained using BSA as model protein. The results showed that the release rate was controllable by varying the composition of the poly(ether ester urethane)s or by adjusting the concentration of the copolymer in the hydrogels. Finally, we studied the correlation between the protein release characteristics of the hydrogels and their hydrolytic degradation. This is the first example that such a correlation has been attempted for a biodegradable thermogelling copolymer system.
机译：本文报道了一系列由聚[（R）-3-羟基丁酸酯]（PHB），聚丙二醇组成的一系列新合成的热凝胶三组分多嵌段聚醚醚酯聚氨酯的水解降解和蛋白质释放的研究。 ）（PPG）和聚（乙二醇）（PEG）。聚（PEG / PPG / PHB氨基甲酸酯）共聚物水凝胶在磷酸盐缓冲液中于pH 7.4和37摄氏度下水解降解长达6个月。获得了共聚物水凝胶的质量损失曲线。通过扫描电子显微镜观察在水解的不同时间段的水凝胶残余物，其显示出随着水解时间增加的孔隙率。缓冲液中的降解产物通过GPC，（1）H NMR，MALDI-TOF和TGA表征。结果表明，PHB链段的酯主链键由于无规断链而断裂，导致分子量降低。另外，发现降解产物的成分是3-羟基丁酸单体和各种长度的低聚物（n ＝ 1-5）。使用BSA作为模型蛋白，可以获得共聚物水凝胶的蛋白释放曲线。结果表明，通过改变聚（醚酯氨基甲酸酯）的组成或通过调节水凝胶中共聚物的浓度，可控制释放速率。最后，我们研究了水凝胶的蛋白质释放特性与其水解降解之间的相关性。这是针对可生物降解的热胶凝共聚物体系尝试这种相关性的第一个例子。

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