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Regulatory role of SH3 domain-mediated protein-protein interactions in synaptic vesicle endocytosis.

机译:SH3结构域介导的蛋白间相互作用在突触囊泡内吞中的调节作用。

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摘要

Src homology (SH) 3 domains are small modules found in a diverse array of proteins. The presence of an SH3 domain confers upon its resident protein the ability to interact with specific proline-rich sequences in protein binding partners. A major focus of research has highlighted a role for SH3 domain-mediated interactions in the regulation of signal transduction events. However, more recent data has suggested an important function for SH3 domains in vesicular trafficking. This review will focus on this newly emerging role with a particular emphasis on the molecular components involved in synaptic vesicle endocytosis and the regulatory role of SH3 domain-mediated protein-protein interactions in this process.
机译:Src同源性(SH)3域是在各种各样的蛋白质中发现的小模块。 SH3结构域的存在赋予其驻留蛋白与蛋白结合伴侣中特定的富含脯氨酸的序列相互作用的能力。研究的主要重点是SH3域介导的相互作用在信号转导事件的调节中的作用。然而,最近的数据表明SH3结构域在水泡运输中具有重要作用。这篇综述将集中于这种新兴的作用,特别是突触小泡内吞作用中涉及的分子成分以及在此过程中SH3结构域介导的蛋白-蛋白相互作用的调节作用。

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