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首页> 外文期刊>Cellular & molecular biology letters. >Platelet-activating factor changes in phospholipid extracts from the plasma, peripheral blood mononuclear cells and bone marrow mononuclear cells of patients with acute leukemia--a 31P MRS in vitro study.
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Platelet-activating factor changes in phospholipid extracts from the plasma, peripheral blood mononuclear cells and bone marrow mononuclear cells of patients with acute leukemia--a 31P MRS in vitro study.

机译：急性白血病患者血浆，外周血单核细胞和骨髓单核细胞的磷脂提取物中的血小板活化因子变化-一项31P MRS体外研究。

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The aim of this investigation was to evaluate the changes in PAF concentrations in the plasma, PBMC and BMMC of patients with acute lymphoblastic leukemia (ALL) and acute myeloblastic leukemia (AML). The plasma was from 23 healthy volunteers (HV) and 44 patients with AL (16 ALL, 28 AML). The PBMC were from 15 HV and 55 patients with AL (18 ALL, 37 AML), and the BMMC from 40 patients with AL (11 ALL, 29 AML). Methanol-chloroform phospholipid extraction from 60 x 10(6) cells (PBMC or BMMC) was performed according to a modified version of Folch's method. (31)P MRS data was obtained on an AMX 300 Bruker spectrometer (7.05 T). The PAF concentration in the plasma of the patients with ALL or AML was lower than that for the healthy volunteers. The PAF concentration in the plasma of the patients with ALL did not differ significantly from that of the patients with AML. In the case of both the PBMC and BMMC, the PAF concentration was significantly diminished in patients with ALL relative to the concentration for those with AML and for the healthy volunteers. No differences were observed in the PAF concentrations for the AML patients and the healthy volunteers.
机译：这项研究的目的是评估急性淋巴细胞白血病（ALL）和急性粒细胞白血病（AML）患者血浆，PBMC和BMMC中PAF浓度的变化。血浆来自23名健康志愿者（HV）和44例AL患者（16 ALL，28 AML）。 PBMC来自15 HV和55例AL（18 ALL，37 AML）患者，而BMMC来自40例AL（11 ALL，29 AML）患者。根据改良的Folch方法，从60 x 10（6）细胞（PBMC或BMMC）中提取甲醇-氯仿磷脂。 （31）P MRS数据是在AMX 300布鲁克光谱仪（7.05 T）上获得的。 ALL或AML患者血浆中PAF浓度低于健康志愿者。 ALL患者的血浆中PAF浓度与AML患者的血浆中PAF浓度无明显差异。对于PBMC和BMMC，ALL患者的PAF浓度相对于AML患者和健康志愿者的PAF浓度显着降低。 AML患者和健康志愿者的PAF浓度未见差异。

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