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首页> 外文期刊>Oncology: International Journal of Cancer Research and Treatment >Gastric and intestinal phenotypic marker expression in gastric carcinomas and its prognostic significance: immunohistochemical analysis of 136 lesions.
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Gastric and intestinal phenotypic marker expression in gastric carcinomas and its prognostic significance: immunohistochemical analysis of 136 lesions.

机译：胃癌肠胃表型标志物的表达及其预后意义：136例病变的免疫组织化学分析。

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摘要

OBJECTIVE: It is well known that both gastric and intestinal phenotypic cell markers are expressed in gastric carcinomas, irrespective of their histologic type. However, the clinicopathologic significance of these expressions has not yet been clarified. METHODS: We analyzed the correlations among gastric and intestinal phenotypic marker expression patterns of the tumor, clinicopathologic findings and the patient's outcome in 136 advanced gastric carcinomas. RESULTS: Phenotypic marker expression was immunohistochemically evaluated using the monoclonal antibodies 45M1 (anti-human gastric mucin; HGM), CLH5 (anti-MUC6), Ccp58 (anti-MUC2) and 56C6 (anti-CD10). All tumors were classified as gastric (G), gastric and intestinal mixed (GI), intestinal (I) or unclassified (UC) phenotype. Of the 136 gastric carcinomas, 50 (36.8%), 56 (41.2%), 21 (15.4%) and 9 (6.6%) were classified as G, GI, I and UC phenotype, respectively. The G-phenotype tumors were associated with a higher rate of undifferentiated-type and infiltrative histology as compared with the I-phenotype tumors (p < 0.05 and p < 0.001, respectively). Furthermore, both univariate and multivariate analysis of survival revealed the G-phenotype tumor to be associated with a significantly poorer outcome than the I-phenotype tumor (p < 0.05). CONCLUSION: Our present results indicate that the gastric and intestinal phenotypic marker expression pattern of tumors, determined by the combination of HGM, MUC6, MUC2 and CD10 expression, is prognostically useful for patients with gastric carcinoma.
机译：目的：众所周知，胃癌和肠表型细胞标志物在胃癌中均表达，无论其组织学类型如何。但是，这些表达的临床病理意义尚未阐明。方法：我们分析了136例晚期胃癌的胃和肠表型标志物表达模式，临床病理结果和患者预后之间的相关性。结果：使用单克隆抗体45M1（抗人胃粘蛋白; HGM），CLH5（抗MUC6），Ccp58（抗MUC2）和56C6（抗CD10）对表型标志物的表达进行了免疫组织化学评估。所有肿瘤分类为胃（G），胃和肠混合（GI），肠（I）或未分类（UC）表型。在136例胃癌中，分别分为G型，GI型，I型和UC型，分别为50（36.8％），56（41.2％），21（15.4％）和9（6.6％）。与I型肿瘤相比，G型肿瘤与未分化型和浸润性组织学的发生率更高（分别为p <0.05和p <0.001）。此外，生存率的单因素和多因素分析均显示，G表型肿瘤的预后明显低于I表型肿瘤（p <0.05）。结论：我们目前的结果表明，由HGM，MUC6，MUC2和CD10表达的组合确定的胃和肠表型标志物表达模式对胃癌患者的预后有用。

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