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首页> 外文期刊>Oncology: International Journal of Cancer Research and Treatment >Reduced Fhit expression occurs in the early stage of esophageal tumorigenesis: no correlation with p53 expression and apoptosis.
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Reduced Fhit expression occurs in the early stage of esophageal tumorigenesis: no correlation with p53 expression and apoptosis.

机译：Fhit表达降低发生在食管肿瘤发生的早期：与p53表达和细胞凋亡无关。

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摘要

The FHIT gene, encompassing the FRA3B fragile site at chromosome 3p14.2, is a candidate tumor suppressor gene involved in multiple tumors, including esophageal carcinoma. We analyzed Fhit expression using an immunohistochemical method in invasive carcinoma, carcinoma in situ (CIS) and dysplasia, in paraffin sections of 75 esophageal squamous cell carcinomas (ESCs) to further elucidate the role of Fhit protein in esophageal carcinogenesis. In addition, we also examined whether Fhit expression correlated with p53 expression and apoptosis. Compared to adjacent normal mucosa, significant loss or reduction of Fhit expression was noted in 67 of 75 (89.3%) invasive ESCs, in 13 of 19 (68.4%) CIS lesions, and in 10 of 23 (43.5%) dysplastic lesions. There was a progressive loss or reduction of Fhit expression with progressive increases in the severity of histopathological changes (p < 0.001). However, there was no association between Fhit expression and clinicopathological findings, including tumor stage, lymph node metastasis, or overall survival. Moreover, Fhit expression was not significantly associated with p53 expression and apoptosis. These results indicate that abnormal Fhit expression is a common event in the early stage of ESC development and may occur independently of p53 expression and apoptosis mechanisms.
机译：FHIT基因包含3p14.2染色体上的FRA3B易碎位点，是涉及多种肿瘤（包括食道癌）的候选肿瘤抑制基因。我们使用免疫组织化学方法分析了75种食管鳞状细胞癌（ESC）石蜡切片中浸润性癌，原位癌（CIS）和异型增生的Fhit表达，以进一步阐明Fhit蛋白在食管癌变中的作用。此外，我们还检查了Fhit表达是否与p53表达和细胞凋亡相关。与相邻的正常黏膜相比，在75个浸润性ESC中有67个（89.3％），在19个CIS病变中有13个（68.4％）和在23个增生性病变中有10个（43.5％）注意到Fhit表达的明显丧失或降低。随着组织病理学改变严重程度的增加，Fhit表达逐渐减少或降低（p <0.001）。但是，Fhit表达与临床病理结果（包括肿瘤分期，淋巴结转移或总体生存）之间没有关联。而且，Fhit表达与p53表达和细胞凋亡没有显着相关。这些结果表明Fhit表达异常是ESC发展早期的常见事件，并且可能独立于p53表达和凋亡机制而发生。

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