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首页> 外文期刊>Oncology: International Journal of Cancer Research and Treatment >Loss of ErbB2 expression in pulmonary metastatic lesions in osteosarcoma.
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Loss of ErbB2 expression in pulmonary metastatic lesions in osteosarcoma.

机译：骨肉瘤肺转移灶中ErbB2表达的丧失。

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OBJECTIVES: The c-erbB2 protooncogene is located on human chromosome 17 and encodes a 185-kilodalton transmembrane glycoprotein (ErbB2). Elevated ErbB2 expression or gene amplification has been shown to be associated with a poor prognosis in many cancers. Recently, it has been demonstrated that overexpression of the ErbB2 protein in osteosarcoma is associated with the presence of pulmonary metastasis and decreased survival. To further investigate the role of ErbB2 overexpression in pulmonary metastasis of osteosarcoma, its expression in the primary and metastatic lesions of the same osteosarcoma patients was compared. METHODS: We compared the expression levels of ErbB2 receptor protein between the biopsy samples and pulmonary metastatic lesions in each of 19 patients with osteosarcoma who had not presented with metastasis at diagnosis. All archival materials from patients were retrieved and stained with monoclonal antibody CB11 to detect ErbB2 protein. RESULTS: The rate of overexpression was significantly lower in the pulmonary metastatic tumors than in the biopsy samples (11 versus 42%; p = 0.03). Among 8 patients who had shown increased levels of ErbB2 in the biopsy samples, 7 exhibited complete absence of ErbB2 in the pulmonary metastatic lesions. Overall loss of ErbB2 expression was noted in 14 of 19 patients as the initial tumor became metastatic. CONCLUSIONS: It is suggested that overexpression of ErbB2 decreases within individual osteosarcomas as they become metastatic. Overexpression of ErbB2 may not play an important role in the development of pulmonary metastases of osteosarcoma. Further data are needed before ErbB2 can be used in making clinical decisions for osteosarcoma patients. Copyright 2001 S. Karger AG, Basel.
机译：目的：c-erbB2原癌基因位于人类17号染色​​体上，编码一个185千达尔顿跨膜糖蛋白（ErbB2）。在许多癌症中，ErbB2表达或基因扩增升高与预后不良有关。最近，已经证明骨肉瘤中ErbB2蛋白的过表达与肺转移的存在和存活率降低有关。为了进一步研究ErbB2过表达在骨肉瘤肺转移中的作用，比较了其在同一骨肉瘤患者原发灶和转移灶中的表达。方法：我们比较了19例在诊断时未出现转移的骨肉瘤患者中，活检样本和肺转移灶之间的ErbB2受体蛋白表达水平。取回患者的所有档案材料，并用单克隆抗体CB11染色以检测ErbB2蛋白。结果：肺转移瘤中的过表达率显着低于活检样品（11％对42％; p = 0.03）。在活检样本中显示ErbB2水平升高的8例患者中，有7例在肺转移病变中显示出ErbB2的完全缺失。随着最初的肿瘤转移，在19名患者中的14名中注意到ErbB2表达的总体丧失。结论：建议个体骨肉瘤中ErbB2的过度表达随着其转移而减少。 ErbB2的过表达可能在骨肉瘤肺转移的发生中不发挥重要作用。在将ErbB2用于骨肉瘤患者的临床决策之前，需要进一步的数据。版权所有2001 S. Karger AG，巴塞尔。

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