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首页> 外文期刊>Oncology: International Journal of Cancer Research and Treatment >Follow-up study in head and neck cancer: cure rate according to tumor location and stage.
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Follow-up study in head and neck cancer: cure rate according to tumor location and stage.

机译：头颈部癌的随访研究：根据肿瘤部位和分期的治愈率。

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摘要

The purpose of this clinical study was to analyze a long-term follow-up of all the patients with head and neck cancer in our institution. Between 1973 and 1993, 1,355 consecutive cases of head and neck cancerwere diagnosed, treated and followed up regularly. All were subjected to a multidisciplinary approach, and followed up until death or for 10 years with no event of disease. The local relapse rate was 20% and the node-regional relapse rate 15%. Distant metastases were observed in 6% of the patients mainly arising from the nasopharynx (23%) followed by the hypopharynx (11%). The main organ involved was the lung (50%). Median follow-up of the group was 10 years (range 4 months to 15 years). Cancer cure was observed after 5 years in glottic and supraglottic laryngeal carcinoma, oral and nasopharyngeal cancer and after 2.5 years in patients with cancer of the oropharynx and hypopharynx. The highest cure rate was 80% in the glottis, followed by 70% in the supraglottic area, 45% in the mouth, 30% in the nasopharynx, 25% in the oropharynx, and 20% in the hypopharynx. A second primary tumor was observed in 7% of the patients and a third primary in 0.6% of the patients. Only in 7 patients, the second or third primary was seen after 5 years of follow-up. Curability should be observed after 5 years from definitive therapy of glottic, supraglottic, oral and nasopharyngeal and earlier in oropharyngeal and hypopharyngeal cancer. Further follow-up should be discontinued. Second and third neoplasias are the main problems after 5 years of follow-up but their incidence is low.
机译：这项临床研究的目的是分析我们机构中所有头颈癌患者的长期随访情况。在1973年至1993年之间，定期诊断，治疗和随访了1,355例连续的头颈癌病例。所有患者均接受多学科研究，随访至死亡或10年无疾病事件。局部复发率为20％，结节区域复发率为15％。在6％的患者中观察到远处转移，主要由鼻咽（23％）其次是下咽（11％）引起。涉及的主要器官是肺（50％）。该组的中位随访时间为10年（范围为4个月至15年）。在声门和声门上喉癌，口腔和鼻咽癌中5年后以及在口咽和下咽癌患者中2.5年后观察到癌症治愈。最高的治愈率在声门上为80％，其次在声门上区域为70％，在口腔中为45％，在鼻咽中为30％，在口咽中为25％，在下咽中为20％。在7％的患者中观察到第二原发肿瘤，在0.6％的患者中观察到第三原发肿瘤。仅在7例患者中，随访5年后才发现第二或第三原发灶。明确治疗声门，声门上，口腔和鼻咽的5年后，以及在口咽和下咽癌的早期应观察到可治愈性。应该停止进一步的随访。继随访5年后，第二和第三次瘤形成是主要问题，但其发生率较低。

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