首页> 外文期刊>Oncology: International Journal of Cancer Research and Treatment >Hand-foot syndrome (hand-foot skin reaction, palmar-plantar erythrodysesthesia): focus on sorafenib and sunitinib.
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Hand-foot syndrome (hand-foot skin reaction, palmar-plantar erythrodysesthesia): focus on sorafenib and sunitinib.

机译:手足综合症(手足皮肤反应,掌-红斑感觉异常):主要集中在索拉非尼和舒尼替尼。

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摘要

Hand-foot syndrome (HFS), also called hand-foot skin reaction, palmar-plantar erythrodysesthesia, acral erythema, and Burgdorf reaction, is a dose-limiting cutaneous toxicity of many chemotherapeutic agents. Recently, the multiple tyrosine kinase inhibitor class of novel targeted therapies, including sorafenib and sunitinib, has emerged as an important cause of HFS, with 10-28% of patients treated with sunitinib and 10-62% of patients treated with sorafenib reporting HFS. This review examines the epidemiology, clinical features, histopathology, pathogenesis models, prognostic implications, and management of HFS, with particular attention to HFS induced by sorafenib and sunitinib. The high prevalence of HFS reported by patients treated with these medications underscores the need for greater understanding of the pathogenesis and management of this syndrome.
机译:手足综合症(HFS),也称为手足皮肤反应,手掌plant足红斑感觉异常,手足红斑和Burgdorf反应,是许多化疗药物的剂量限制性皮肤毒性反应。最近,包括索拉非尼和舒尼替尼在内的新型靶向疗法的多种酪氨酸激酶抑制剂类别已成为HFS的重要病因,舒尼替尼治疗的患者占10-28%,索拉非尼治疗的患者占10-62%。这篇综述检查了HFS的流行病学,临床特征,组织病理学,发病机制模型,预后意义和治疗,尤其关注索拉非尼和舒尼替尼引起的HFS。用这些药物治疗的患者报告的HFS患病率很高,这凸显了对这种综合征的发病机理和治疗方法的深入了解的必要性。

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