Signalling via the hypoxia-inducible factor-1 alpha requires multiple posttranslational mofications

Brahimi-Horn C; Mazure N; Pouyssegur J

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Signalling via the hypoxia-inducible factor-1 alpha requires multiple posttranslational mofications

机译：通过缺氧诱导因子-1α进行信号转导需要多个翻译后修饰

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Cellular hypoxia, a local decrease in the oxygen concentration below normal (21%) atmospheric concentrations, occurs in both physiological and pathological situations. The transcriptional complex Hypoxia-Inducible Factor-1 (HIF-1) is the key player in the signalling pathway that controls the hypoxic response of mammalian cells. Tight regulation of this response involves posttranslational modification of the alpha subunit of HIF-1. Hydroxylation, ubiquitination, acetylation, S-nitrosation and phosphorylation have been shown to determine its half-life and/or transcriptional activity. The precise spatio-temporal occurrence of these multiple modifications is still not fully understood but is dependent on the microenvironment and determines the driving force of variable cellular responses. (C) 2004 Elsevier Inc. All rights reserved.

机译：在生理和病理情况下都会发生细胞缺氧，即氧气浓度低于正常（21％）大气浓度的局部降低。转录复合物低氧诱导因子-1（HIF-1）是控制哺乳动物细胞低氧反应的信号传导途径中的关键角色。对该反应的严格调节涉及HIF-1的α亚基的翻译后修饰。羟基化，泛素化，乙酰化，S-亚硝化和磷酸化已显示决定其半衰期和/或转录活性。这些多重修饰的精确时空发生仍未完全了解，但取决于微环境并确定可变细胞应答的驱动力。（C）2004 Elsevier Inc.保留所有权利。

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《Cellular Signalling》 |2005年第1期|共9页
作者
Brahimi-Horn C; Mazure N; Pouyssegur J;
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正文语种 eng
中图分类细胞形态学;
关键词
angiogenesis; arrest defective-protein; cancer; hypoxia; hypoxia-inducible factor; posttranslational modification; prolyl-4-hydroxylase; LINDAU TUMOR-SUPPRESSOR; N-TERMINAL ACETYLTRANSFERASE; OXYGEN-SENSING PATHWAY; RNA-POLYMERASE-II; TRANSCRIPTIONAL ACTIVITY; GENE-EXPRESSION; FACTOR 1-ALPHA; HIF-ALPHA; PROLINE HYDROXYLATION; PROLYL 4-HYDROXYLASES;

机译：血管生成;逮捕性缺陷蛋白;癌症;缺氧;缺氧诱导因子;翻译后修饰;脯氨酰-4-羟化酶;Lindau肿瘤抑制因子;N-末端乙酰转移酶;氧敏感途径;RNA-聚合酶-II;转录活性;生成-表达;因子1-α;HIF-α;脯氨酸羟基化;脯氨酸4-羟基;

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1. Signalling via the hypoxia-inducible factor-1 alpha requires multiple posttranslational mofications [J] . Brahimi-Horn C, Mazure N, Pouyssegur J Cellular Signalling . 2005,第1期

机译：通过缺氧诱导因子-1α进行信号转导需要多个翻译后修饰
2. Notch signaling represses hypoxia-inducible factor-1 alpha-induced activation of Wnt/beta-catenin signaling in osteoblasts under cobalt-mimicked hypoxia [J] . Li Chen-Tian, Liu Jian-Xiu, Yu Bo, Molecular medicine reports . 2016,第1aPta1期

机译：Notch信号抑制钴模拟缺氧条件下成骨细胞中缺氧诱导因子-1α诱导的Wnt /β-catenin信号激活
3. Curcumol inhibits the expression of programmed cell death-ligand 1 through crosstalk between hypoxia-inducible factor-1 alpha and STAT3 (T705) signaling pathways in hepatic cancer [J] . Journal of Ethnopharmacology: An Interdisciplinary Journal Devoted to Bioscientific Research on Indigenous Drugs . 2020,第期

机译：Curcumol抑制编程细胞死亡 - 配体1的表达通过肝癌中缺氧诱导因子-1α和Stat3（T705）信号传导途径之间的串扰表达
4. Hypoxia-inducible factor-1/spl alpha/ (HIF-1/spl alpha/) and photodynamic therapy [C] . Lin-Hung Wei, Chia-Hung Chou, Jen-Liang Su . 2004

机译：缺氧诱导因子-1 / spl alpha /（HIF-1 / spl alpha /）和光动力疗法
5. Hypoxia-inducible factor-1 alpha (HIF-1alpha) and its role in the hypoxic preconditioning and gene expression patterns in zebrafish ( Danio rerio) embryos. [D] . Mohamed, Amira F. 2007

机译：低氧诱导因子-1α（HIF-1alpha）及其在斑马鱼（Danio rerio）胚胎的低氧预处理和基因表达模式中的作用。
6. Activation of Dll4/Notch Signaling and Hypoxia-Inducible Factor-1 Alpha Facilitates Lymphangiogenesis in Lacrimal Glands in Dry Eye [O] . Ji Hwan Min, Chul Hee Lee, Yong Woo Ji, -1

机译：Dll4 / Notch信号和缺氧诱导因子-1α的激活促进干眼泪腺的淋巴管生成。
7. Activation of Dll4/Notch Signaling and Hypoxia-Inducible Factor-1 Alpha Facilitates Lymphangiogenesis in Lacrimal Glands in Dry Eye. [O] . Ji Hwan Min, Chul Hee Lee, Yong Woo Ji, 2016

机译：Dll4 / Notch信号和缺氧诱导因子-1α的激活促进干眼泪腺中的淋巴管生成。

Signalling via the hypoxia-inducible factor-1 alpha requires multiple posttranslational mofications

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