• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cellular Signalling >FGFR4 GLY388 isotype suppresses motility of MDA-MB-231 breast cancer cells by EDG-2 gene repression
【24h】

FGFR4 GLY388 isotype suppresses motility of MDA-MB-231 breast cancer cells by EDG-2 gene repression

机译：FGFR4 GLY388同型通过EDG-2基因抑制抑制MDA-MB-231乳腺癌细胞的运动

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Clinical investigations of an FGFR4 germline polymorphism, resulting in substitution of glycine by arginine at codon 388 (G388 to R388), have shown a correlation between FGFR4 R388 and aggressive disease progression in cancer patients. Here, we studied the differential effects of the two FGFR4 isotypes on cellular signalling and motility in the MDA-MB-231 human breast cancer cell model. cDNA array analysis showed the ability of FGFR4 G388 to suppress expression of specific genes involved in invasiveness and motility. Further investigations concentrating on cell signalling and motility revealed an abrogation of phosphatidylinositol-3-kinase-dependent LPA-induced Akt activation and cell migration due to downregulation of the LPA receptor Edg-2 in FGFR4 G388-expressing MDA-MB-231 cells. Moreover, FGFR4 G388 expression attenuated the invasivity of the breast cancer cell line and decreased small Rho GTPase activity. We conclude that FGFR4 G388 suppresses cell motility of invasive breast cancer cells by altering signalling pathways and the expression of genes that are required for metastasis. Therefore, the positive effect of FGFR4 R388 on disease progression appears to result from a loss of the tumour suppressor activity displayed by FGFR4 G388 rather than the acquisition or enhancement of oncogenic potential. (c) 2005 Elsevier Inc. All rights reserved.
机译：FGFR4种系多态性的临床研究导致在388位密码子（G388至R388）处的精氨酸取代了甘氨酸，已表明FGFR4 R388与癌症患者的侵袭性疾病进展相关。在这里，我们研究了两种FGFR4同种型对MDA-MB-231人乳腺癌细胞模型中细胞信号传导和运动的不同影响。 cDNA阵列分析显示了FGFR4 G388抑制涉及侵袭性和运动性的特定基因表达的能力。集中于细胞信号传导和运动的进一步研究表明，由于表达FGFR4 G388的MDA-MB-231细胞中LPA受体Edg-2的下调，磷脂酰肌醇-3-激酶依赖性LPA诱导的Akt活化和细胞迁移被废止。此外，FGFR4 G388表达减弱了乳腺癌细胞系的侵袭性，并降低了小的Rho GTPase活性。我们得出结论，FGFR4 G388通过改变信号通路和转移所需基因的表达来抑制侵袭性乳腺癌细胞的细胞运动。因此，FGFR4 R388对疾病进展的积极作用似乎是由于FGFR4 G388表现出的肿瘤抑制活性丧失，而不是获得或增强致癌潜能所致。 （c）2005 Elsevier Inc.保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号