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首页> 外文期刊>Reproductive toxicology >Assessment of estrogenicity by using the delayed implanting rat model and examples.
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Assessment of estrogenicity by using the delayed implanting rat model and examples.

机译：通过使用延迟植入大鼠模型和实施例评估雌激素。

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Endocrine disrupting chemicals have recently drawn increased interest. The delayed implanting rat model is a method that can identify and quantify the estrogenic activity of a chemical. In rats hypophysectomized after breeding, the administration of progesterone delays embryo implantation, and exposure to one dose of an estrogenic substance initiates implantation. Although methoxychlor was ineffective at dosages below 400 mg/kg when given by injection, the administration of the chemical by gavage resulted in an increase in the percent of fertilized rats exhibiting implantation sites. These results were statistically significant at dosages of 50, 100, 200, and 300 mg methoxychlor/kg. When bisphenol A was administered, by subcutaneous injection, dosages of 50, 100, and 200 mg/kg induced implantation. Only the 400 mg/kg dose of 4-tert-octylphenol was effective. Doses of beta-sitosterol up to 30 mg/kg failed to initiate implantation. These data confirm previous evidence of the availability of this model for evaluating estrogenic activity and provide estimates of the estrogenic potencies of several environmentally important chemicals.
机译：最近，破坏内分泌的化学物质引起了越来越多的关注。延迟植入大鼠模型是一种可以识别和量化化学物质雌激素活性的方法。在繁殖后进行了切除术的大鼠中，黄体酮的给药会延迟胚胎的植入，而暴露于一剂雌激素中会引发植入。尽管当注射时甲氧基氯在低于400 mg / kg的剂量下无效，但通过管饲法施用该化学品导致受精大鼠表现出植入位点的百分比增加。在50、100、200和300 mg甲氧基氯/ kg的剂量下，这些结果具有统计学意义。当通过皮下注射给予双酚A时，剂量为50、100和200 mg / kg诱导植入。只有400 mg / kg剂量的4-叔辛基苯酚有效。剂量高达30 mg / kg的β-谷甾醇未能启动植入。这些数据证实了该模型可用于评估雌激素活性的先前证据，并提供了几种对环境重要的化学物质的雌激素效力的估计。

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