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首页> 外文期刊>Reproductive toxicology >Developmental toxic effects of chronic exposure to high doses of iodine in the mouse.
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Developmental toxic effects of chronic exposure to high doses of iodine in the mouse.

机译：小鼠长期暴露于高剂量碘的发育毒性作用。

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摘要

Chronic exposure to high doses of iodine induces thyroid dysfunction, but effects of chronic exposure to high amounts of iodine on pregnancy and fetal outcome are uncertain. In the present study, Balb/C mice were given different doses of iodine at the levels of 0 (sterile water), 1,500, 3,000, 6,000, 12,000 and 24,000 micro g/L in drinking water for 4 months, then were mated and the developmental toxicity and teratogenicity were evaluated. An obvious colloid goiter was observed, and serum total thyroxine (TT4) levels increased and serum total triiodothyronine (TT3) levels decreased significantly in dams when iodine dose reached 3,000 micro g/L. Maternal effect was evident by the reduction of average daily food consumption in higher doses of iodine groups. Embryotoxicity and teratogenicity were mainly indicated by the reduced body weight in female fetuses, the decreased number of live fetuses, and the increased incidence of resorptions, and especially skeletal variations. These results suggest that exposure to maternally toxic doses of iodine may have a potential developmental toxic effect.
机译：长期暴露于高剂量的碘会引起甲状腺功能障碍，但长期暴露于高碘对怀孕和胎儿结局的影响尚不确定。在本研究中，Balb / C小鼠在饮用水中分别以0（无菌水），1,500、3,000、6,000、12,000和24,000 micro g / L的水平给予不同剂量的碘，持续4个月，然后进行交配并评价了发育毒性和致畸性。当碘量达到3,000 micro g / L时，大坝中的血清总甲状腺素（TT4）水平升高，血清总三碘甲状腺素（TT3）水平显着下降。较高剂量的碘组降低平均每日食物消耗量，可以明显地看出产妇的作用。胚胎毒性和致畸性主要表现为雌性胎儿体重减轻，活胎数量减少，吸收率增加，尤其是骨骼变异。这些结果表明，暴露于母体毒性剂量的碘可能具有潜在的发育毒性作用。

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