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首页> 外文期刊>Reproductive toxicology >Repeated administration of diphenyl diselenide to pregnant rats induces adverse effects on embryonic/fetal development.
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Repeated administration of diphenyl diselenide to pregnant rats induces adverse effects on embryonic/fetal development.

机译：对怀孕的大鼠重复给予二苯二硒化物诱导对胚胎/胎儿发育的不利影响。

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摘要

The present study was carried out to investigate the effects of diphenyl diselenide, (PhSe)(2), on embryo-fetal development. Dams were treated subcutaneously with 1.5, 3.0 and 6.0 mg/kg (PhSe)(2) from days 6 to 15 of pregnancy. After cesarean section at gestation day (GD) 20, external and skeletal abnormalities were evaluated. A decrease in maternal body weight gain was found in (PhSe)(2) groups, indicating maternal toxicity. There was a reduction in the fetal weight and in crown-rump (CR) length of fetuses at three doses tested. The occipito-nasal length decreased in fetuses from dams exposed to 3.0 mg/kg (PhSe)(2). Signs of delayed ossification in the skull, sternebrae and limbs were observed in all (PhSe)(2) groups, revealing a relation between morphological alterations and growth retardation in fetuses, but none of the changes appeared to be dose-dependent. Exposure of dams to (PhSe)(2) resulted in altered placental morphology that may have contributed to adverse reproductive outcomes. We concludedthat (PhSe)(2) is toxic to dams and induces developmental delay of the fetal skeleton, but does not cause externally visible malformations in rat fetuses, in this experimental procedure.
机译：本研究旨在研究二苯基二硒化物（PhSe）（2）对胚胎-胎儿发育的影响。从怀孕的第6天到第15天，对大坝分别进行1.5、3.0和6.0 mg / kg（PhSe）（2）的皮下治疗。妊娠第20天剖腹产后，评估外部和骨骼异常。在（PhSe）（2）组中发现孕产妇体重增加减少，表明孕产妇毒性。在三种测试剂量下，胎儿的体重和冠状臀围（CR）长度均减少。暴露于3.0 mg / kg（PhSe）（2）的水坝中胎儿的枕鼻长度减少。在所有（PhSe）（2）组中均观察到头骨，胸骨和四肢骨化延迟的迹象，揭示了胎儿的形态改变与生长迟缓之间的关系，但这些改变似乎都不是剂量依赖性的。将大坝暴露于（PhSe）（2）会导致胎盘形态改变，这可能导致不良的生殖结果。我们得出的结论是，在该实验程序中，（PhSe）（2）对大坝有毒并诱导胎儿骨骼发育延迟，但不会在大鼠胎儿中引起外部可见的畸形。

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