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首页> 外文期刊>Reproductive toxicology >The protective effects of melatonin and Vitamin E on antioxidant enzyme activities and epididymal sperm characteristics of homocysteine treated male rats.
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The protective effects of melatonin and Vitamin E on antioxidant enzyme activities and epididymal sperm characteristics of homocysteine treated male rats.

机译：褪黑素和维生素E对高半胱氨酸处理的雄性大鼠抗氧化酶活性和附睾精子特性的保护作用。

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The aims of this study were to investigate the effects of homocysteine (Hcy) on epididymal sperm characteristics, plasma testosterone level and biochemical changes related to oxidative stress and to examine the effects of melatonin (Mlt) or Vitamin E (VE) administration on these parameters in Hcy-treated male rats. In this study, 32 adult male albino rats of Wistar strain were used. The rats were randomly divided into four groups. The first group of rats received only Hcy (0.71 mg/kg/day) intraperitonially (ip) for 6 weeks. The second group of rats was given Hcy along with simultaneous administration of Mlt (1mg/kg/day) subcutaneously. The third group of rats received Hcy along with simultaneous administration of VE (125 mg/kg/day, ip). The fourth group of rats served as control during 6 weeks and was daily given 0.1 mL of physiological saline (NaCl, 0.9%) ip. While the plasma malondialdehyde level significantly (p<0.05) increased, the plasma superoxide dismutase, glutathione peroxidase and catalase activities significantly (p<0.05) decreased in Hcy-treated rats when compared to control rats. Furthermore, the epididymal sperm concentration, the percentage of progressive sperm motility and plasma testosterone level were significantly (p<0.05) lower in Hcy-treated rats than those of the control rats. The simultaneous administration of Mlt or VE to Hcy-treated animals impeded the decrease in the plasma antioxidant enzyme activities, testosterone level, the epididymal sperm concentration and motility. In conclusion, this study indicates that chronic administration of Hcy has the harmful effect on the epididymal sperm characteristics of male rats. The administration of Mlt or VE can prevent adverse effects of Hcy on the plasma antioxidant enzyme activities, testosterone level, epididymal sperm count and motility in male rats.
机译：这项研究的目的是调查高半胱氨酸（Hcy）对附睾精子特征，血浆睾丸激素水平和与氧化应激有关的生化变化的影响，并研究褪黑激素（Mlt）或维生素E（VE）对这些参数的影响在Hcy治疗的雄性大鼠中。在这项研究中，使用Wistar品系的32只成年雄性白化病大鼠。将大鼠随机分为四组。第一组大鼠腹膜内（ip）仅接受Hcy（0.71 mg / kg /天），持续6周。给第二组大鼠Hcy并同时皮下注射Mlt（1mg / kg / day）。第三组大鼠接受Hcy并同时服用VE（125 mg / kg / day，ip）。第四组大鼠在6周内作为对照组，每天腹腔注射0.1 mL生理盐水（NaCl，0.9％）。与对照组相比，Hcy处理的大鼠血浆丙二醛水平显着增加（p <0.05），血浆超氧化物歧化酶，谷胱甘肽过氧化物酶和过氧化氢酶活性显着降低（p <0.05）。此外，Hcy治疗的大鼠的附睾精子浓度，进行性精子运动百分比和血浆睾丸激素水平显着低于对照组（p <0.05）。向Hcy处理的动物同时施用Mlt或VE阻止了血浆抗氧化酶活性，睾丸激素水平，附睾精子浓度和运动能力的降低。总之，这项研究表明，长期服用Hcy对雄性大鼠附睾精子特征具有有害作用。施用Mlt或VE可预防Hcy对雄性大鼠血浆抗氧化酶活性，睾丸激素水平，附睾精子数量和运动性的不利影响。

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