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首页> 外文期刊>Reproductive toxicology >Pathological modifications following sub-chronic exposure of medaka fish (Oryzias latipes) to microcystin-LR.
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Pathological modifications following sub-chronic exposure of medaka fish (Oryzias latipes) to microcystin-LR.

机译：将青aka鱼（Oryzias latipes）亚慢性暴露于微囊藻毒素-LR后的病理改变。

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Microcystins (MCs) are toxic monocyclic heptapeptides produced by many cyanobacteria. MCs, especially MC-LR, cause toxic effects in animals and are a recognized potent cause of environmental stress and health hazard in aquatic ecosystems when heavy blooms of cyanobacteria appear. Consequently, one of the major problems is the chronic exposure of fish to cyanotoxins in their natural environment. The present experiment involving chronic exposure confirmed initial findings on acute exposure to MC contamination: exacerbated physiological stress and tissue damage in several tissues of exposed medaka fish. The gonads were affected specifically. In female gonads the modifications included reduction of the vitellus storage, lysis of the gonadosomatic tissue and disruption of the relationships between the follicular cells and the oocytes. In the males, spermatogenesis appeared to be disrupted. This is the first report showing that a cyanotoxin can affect reproductive function, and so can impact on fish reproduction and thus fish stocks.
机译：微囊藻毒素（MCs）是许多蓝细菌产生的有毒的单环七肽。 MCs，特别是MC-LR，在动物中引起毒性作用，并且是当蓝藻大量繁殖出现时在水生生态系统中引起环境压力和健康危害的公认有效原因。因此，主要问题之一是鱼在自然环境中长期暴露于氰毒素中。目前涉及慢性暴露的实验证实了急性暴露于MC污染的初步发现：加剧了暴露的鱼几种组织的生理压力和组织损伤。性腺受到特别的影响。在雌性性腺中，修饰包括减少卵黄储，减少性腺体组织的溶解以及破坏卵泡细胞和卵母细胞之间的关系。在男性中，精子发生似乎被破坏。这是第一个报告，表明氰毒素可以影响生殖功能，因此可以影响鱼类繁殖，进而影响鱼类种群。

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