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首页> 外文期刊>Reproductive toxicology >Pregnancy loss and eye malformations in offspring of F344 rats following gestational exposure to mixtures of regulated trihalomethanes and haloacetic acids.
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Pregnancy loss and eye malformations in offspring of F344 rats following gestational exposure to mixtures of regulated trihalomethanes and haloacetic acids.

机译：妊娠暴露于调节性三卤甲烷和卤代乙酸的混合物后，F344大鼠后代的妊娠损失和眼畸形。

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摘要

Chlorination of drinking water yields hundreds of disinfection by-products (DBPs). Among the DBPs, four trihalomethanes (THMs; chloroform, bromodichloromethane, chlorodibromomethane, bromoform) and five haloacetic acids (HAAs; chloroacetic, dichloroacetic, trichloroacetic, bromoacetic, and dibromoacetic acid) are U.S. EPA regulated. We assessed the combined toxicity of these DBPs. F344 rats were treated with mixtures of the four THMs (THM4), the five HAAs (HAA5), or nine DBPs (DBP9; THM4+HAA5). Mixtures were administered in 10% Alkamuls((R)) EL-620 daily by gavage on gestation days 6-20. Litters were examined postnatally. All three mixtures caused pregnancy loss at >/= 613 mumol/kg/day. In surviving litters, resorption rates were increased in groups receiving HAA5 at 615 mumol/kg/day and DBP9 at 307 mumol/kg/day. HAA5 caused eye malformations (anophthalmia, microphthalmia) at >/= 308 mumol/kg/day. Thus, both HAAs and THMs contributed to DBP9-induced pregnancy loss. The presence of THMs in the full mixture, however, appeared to reduce the incidence of HAA-induced eye defects.
机译：饮用水的氯化产生数百种消毒副产物（DBP）。在DBP中，有4种三卤甲烷（THM;氯仿，溴代二氯甲烷，氯代二溴甲烷，溴仿）和5种卤代乙酸（HAA;氯乙酸，二氯乙酸，三氯乙酸，溴乙酸和二溴乙酸）受美国EPA管制。我们评估了这些DBP的综合毒性。用四个THM（THM4），五个HAA（HAA5）或九个DBP（DBP9; THM4 + HAA5）的混合物治疗F344大鼠。在妊娠第6-20天每天通过管饲法在10％Alkamuls？EL-620中施用混合物。产后检查产仔。所有这三种混合物导致流产> / = 613 mumol / kg / day。在存活的幼仔中，接受HAA5剂量为615μmol/ kg /天和DBP9剂量为307μmol/ kg /天的组的吸收率增加。 HAA5以> / = 308μmol/ kg / day的天数引起眼畸形（弱视，小眼）。因此，HAA和THM均导致DBP9诱导的妊娠流失。然而，在全部混合物中THM的存在似乎减少了HAA诱导的眼缺陷的发生。

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