• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Reproductive toxicology >Abnormal peripubertal development of the rat mammary gland following exposure in utero and during lactation to a mixture of genistein and the food contaminant vinclozolin.
【24h】

Abnormal peripubertal development of the rat mammary gland following exposure in utero and during lactation to a mixture of genistein and the food contaminant vinclozolin.

机译：在子宫内暴露和泌乳期间，染料木黄酮和食物污染物长春新唑的混合物会使大鼠乳腺的青春期发育异常。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The impact of early exposure to endocrine disruptor mixtures on mammary gland development is poorly known. Here, we identify the effects of a conception to weaning exposure of rats to the phytoestrogen genistein (G) and/or the antiandrogen vinclozolin (V) at 1mg/kg-d, alone or in association. Using several approaches, we found that G- and GV-exposed rats displayed significantly greater epithelial branching and proliferation, wider terminal end buds than controls at PND35, as well as ductal hyperplasia and periductal fibrosis. Focal branching defects were present in V-exposed rats. An increased ER and AR expression was observed in G- and GV- as compared to V-exposed rats at PND35. Surprisingly, a significant number of GV- and to a lesser extent, V-exposed animals displayed abnormal hyperplasic alveolar structures at PND50. Thus, gestational and lactational exposure to low doses of genistein plus vinclozolin may seriously affect peripubertal development of the rat mammary gland.
机译：早期接触内分泌干扰物混合物对乳腺发育的影响知之甚少。在这里，我们确定了一种概念对断奶大鼠单独或联合服用1mg / kg-d的植物雌激素染料木黄酮（G）和/或抗雄激素长春新唑啉（V）的影响。使用几种方法，我们发现暴露于G和GV的大鼠比PND35的对照组显示出明显更大的上皮分支和增殖，更宽的末端芽，以及导管增生和导管周围纤维化。 V暴露的大鼠中存在局灶性分支缺损。在PND35，与暴露于V的大鼠相比，在G和GV-中观察到ER和AR表达增加。出人意料的是，大量的GV-和较小程度的V-暴露的动物在PND50处显示出异常的增生性肺泡结构。因此，妊娠期和哺乳期暴露于低剂量的染料木黄酮加长春新唑啉可能会严重影响大鼠乳腺的青春期发育。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号