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首页> 外文期刊>Reproductive toxicology >Differential effects of p,p'-DDE on testis and liver mitochondria: implications for reproductive toxicology.
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Differential effects of p,p'-DDE on testis and liver mitochondria: implications for reproductive toxicology.

机译：p，p'-DDE对睾丸和肝线粒体的差异作用：对生殖毒理学的影响。

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The release of environmental contaminants can contribute to impaired male fertility. The bioenergetics of isolated liver mitochondria have been used as a toxicological indicator, an inexpensive first line model to screen possible effects of several substances. Here we report the effects of 2,2-bis(4-chlorophenyl)-1,1-dichloro-ethylene (DDE) on the bioenergetical parameters of testicular mitochondria. A significant decrease in repolarization potential (after a phosphorylative cycle), state 3 respiration and uncoupled respiration, with a concomitant increase in lag phase was found, demonstrating a decrease in mitochondrial function. Importantly, there was also a clear increase in maximum potential in DDE-treated testis mitochondria, which was not mirrored by more commonly used liver mitochondria. Indeed, comparative studies showed that testis and liver mitochondria have strikingly different sensitivities and patterns of response to DDE, indicating that testis mitochondria should be used as a primary toxicological model for a proper evaluation of putative effects of environmental toxicants on the bioenergetics of spermatogenesis and male fertility.
机译：环境污染物的释放会导致男性生育能力受损。分离的肝线粒体的生物能已被用作毒理学指标，这是一种廉价的第一线模型，可以筛选几种物质的可能作用。在这里我们报告2,2-双（4-氯苯基）-1,1-二氯乙烯（DDE）对睾丸线粒体生物能参数的影响。发现复极化电位（在磷酸化循环后），状态3呼吸和非耦合呼吸显着下降，同时伴有迟滞期增加，表明线粒体功能下降。重要的是，DDE治疗的睾丸线粒体的最大潜力也明显增加，而更常用的肝线粒体并未反映出这一点。确实，比较研究表明，睾丸和肝线粒体对DDE的敏感性和反应模式截然不同，这表明睾丸线粒体应被用作主要的毒理学模型，以正确评估环境毒物对精子发生和男性雄性生物能的推定作用。生育能力。

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