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首页> 外文期刊>Reproductive toxicology >Effect of perinatal and postnatal bisphenol A exposure to the regulatory circuits at the hypothalamus-pituitary-gonadal axis of CD-1 mice.
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Effect of perinatal and postnatal bisphenol A exposure to the regulatory circuits at the hypothalamus-pituitary-gonadal axis of CD-1 mice.

机译：围产期和产后双酚A暴露于CD-1小鼠下丘脑-垂体-性腺轴的调节回路中的作用。

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摘要

Bisphenol A (BPA) is used in the manufacture of many products and is ubiquitous in the environment. Adverse effects of BPA on animal reproductive health have been reported, however most of the studies relied on the approaches in the assessment of conventional histology and anatomical features. The mechanistic actions of BPA are not clear. In the present study, a murine model was used to study potential effects of BPA exposure during perinatal and postnatal periods on endocrine functions of hypothalamic-pituitary-gonadal (HPG)-axis. At the hypothalamic-pituitary level, BPA exposure resulted in the up-regulation of the expression levels of KiSS-1, GnRH and FSH mRNA in both male and female pups. At the gonadal levels, BPA caused inhibition in the expressions of testicular steroidogenic enzymes and the synthesis of testosterone in the male pups. Conversely exposure to BPA resulted in a greater aromatase expression level and the synthesis of estrogen in the female pups. BPA is a weak estrogen agonist and its effects reported on animal studies are difficult to reconcile with mechanistic action of estrogen. In this study we hypothesized that the effects of BPA on reproductive dysfunction may be due to its actions on gonadal steroidogenesis and so the anomalous releases of endogenous steroid hormones. This non-ER-mediated effect is more potent in affecting the feedback regulatory circuits in the HPG-axis.
机译：双酚A（BPA）用于制造许多产品，并且在环境中无处不在。已经报道了双酚A对动物生殖健康的不利影响，但是大多数研究都依赖于评估常规组织学和解剖学特征的方法。 BPA的机械作用尚不清楚。在本研究中，使用鼠模型来研究围产期和产后BPA暴露对下丘脑-垂体-性腺（HPG）轴的内分泌功能的潜在影响。在下丘脑-垂体水平，BPA暴露导致雄性和雌性幼犬的KiSS-1，GnRH和FSH mRNA表达水平上调。在性腺水平，双酚A会抑制雄性幼崽睾丸类固醇生成酶的表达和睾丸激素的合成。相反，暴露于BPA会导致雌性幼仔中更高的芳香化酶表达水平和雌激素合成。 BPA是一种弱的雌激素激动剂，在动物研究中报告的作用很难与雌激素的机械作用相协调。在这项研究中，我们假设BPA对生殖功能障碍的影响可能是由于其对性腺类固醇生成的作用，因此内源性类固醇激素的异常释放。这种非ER介导的作用在影响HPG轴上的反馈调节电路方面更为有效。

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