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首页> 外文期刊>Reproductive toxicology >Toxic trace metals and embryo quality indicators during in vitro fertilization (IVF).
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Toxic trace metals and embryo quality indicators during in vitro fertilization (IVF).

机译：体外受精（IVF）过程中的有毒微量金属和胚胎质量指标。

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摘要

Trace exposures to the toxic metals mercury (Hg), cadmium (Cd) and lead (Pb) may interfere with in vitro fertilization (IVF). The aim of this study is to explore biologically plausible hypotheses concerning associations between metals and embryo quality indicators during IVF. For 24 female patients, a multivariable ordinal logistic regression model suggests a 75% reduction in the odds for higher embryo cell cleavage per mug/dL increase in blood Pb (adjusted odds ratio (aOR) 0.25, 95% confidence interval (CI) 0.07-0.86). For 15 male partners, each mug/L increase in blood Hg (aOR 0.60, 95% CI 0.45-0.79) and mug/dL increase in blood Pb (aOR 0.58, 95% CI 0.37-0.91) is associated with a decrease in the analogous odds. Embryo fragmentation is reduced by higher blood Hg (aOR 0.85, 95% CI 0.72-1.00), but increased by higher blood Pb (aOR 1.47, 95% CI 1.11-1.94) in men. The magnitude of these suggested effects warrants confirmation in a larger study.
机译：微量暴露于有毒金属汞（Hg），镉（Cd）和铅（Pb）可能会干扰体外受精（IVF）。这项研究的目的是探讨有关IVF期间金属与胚胎质量指标之间关联的生物学上合理的假设。对于24位女性患者，多变量有序Logistic回归模型表明，血液杯中每杯啤酒/ dl血液中铅的增加，较高的胚胎细胞分裂几率降低了75％（调整后的优势比（aOR）0.25，95％置信区间（CI）0.07- 0.86）。对于15个男性伴侣，每杯血液中的Hg升高（aOR 0.60，95％CI 0.45-0.79）和每杯血液中Pb升高（aOR 0.58，95％CI 0.37-0.91）与降低类似的赔率。男性血液中较高的Hg（aOR 0.85，95％CI 0.72-1.00）减少了胚胎破碎，但是血液中较高的Pb（aOR 1.47，95％CI 1.11-1.94）增加了胚胎碎裂。这些建议作用的程度值得在更大的研究中证实。

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