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首页> 外文期刊>Reproductive toxicology >Reproductive and developmental toxicities of zinc supplemented rats.
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Reproductive and developmental toxicities of zinc supplemented rats.

机译：锌补充大鼠的生殖和发育毒性。

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摘要

Reproductive and developmental toxicities of zinc supplementation in F(0) rats and F(1) progeny were examined. Rats were treated by gavaging with zinc chloride (ZnCl(2)) at 0.0, 7.5, 15 and 30 mg/kg-d. ZnCl(2) treatment was associated with deficient energy imbalances, reduced number of live pups/litter, decreased live birth index, increased mortality and increased fetal resorption. Changes in serum clinical chemistry and hematologic parameters were sex-related. In F(0) females, ZnCl(2) was associated with increased liver/body weight ratios, reduced creatinine and reduced alkaline phosphatase concentrations. In F(0) males, ZnCl(2) significantly increased relative liver weight and elevated gamma-GGT. In addition, at birth, F(1) males exhibited, a significant (p<0.05) increase in anogenital distance, whereas ZnCl(2) hastened the time of eye opening and incisor eruption in males and females. These results indicate that excess ZnCl(2) supplementation before and during pregnancy and during lactation could pose some health risk concerns to pregnant mothers and their offspring.
机译：锌的补充对F（0）大鼠和F（1）后代的生殖和发育毒性。通过以0.0、7.5、15和30 mg / kg-d的氯化锌（ZnCl（2））灌胃处理大鼠。 ZnCl（2）治疗与能量不平衡不足，幼仔/幼仔数量减少，活产指数降低，死亡率增加和胎儿吸收增加有关。血清临床化学和血液学参数的变化与性别有关。在F（0）女性中，ZnCl（2）与肝脏/体重比增加，肌酐减少和碱性磷酸酶浓度降低有关。在F（0）男性中，ZnCl（2）显着增加了相对肝脏的重量并提高了γ-GGT。此外，在出生时，F（1）男性表现出明显的肛门生殖器距离增加（p <0.05），而ZnCl（2）加快了男性和女性的睁眼时间和门牙喷发的时间。这些结果表明，怀孕前，怀孕期间和哺乳期间过量补充ZnCl（2）可能会对怀孕的母亲及其后代造成一些健康风险问题。

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