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首页> 外文期刊>Reproductive toxicology >Hormonal and reproductive disturbances in epileptic male patients: emerging issues.
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Hormonal and reproductive disturbances in epileptic male patients: emerging issues.

机译：癫痫男性患者的激素和生殖功能紊乱：新出现的问题。

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OBJECTIVE: To review the relationship between epilepsy, antiepileptic drugs and reproductive function. METHODS: Pertinent articles were identified through a computer PubMed search. References of selected articles were hand searched for additional citations. CONCLUSIONS: Disturbances of reproductive endocrine hormones occur more frequently in men with epilepsy than in the general population; they manifest as loss of libido, impotence and infertility. These disturbances can be caused by epilepsy itself, by chronic use of antiepileptic drugs (AEDs) or both. AEDs can induce various hormonal abnormalities; in particular, the use of the liver enzyme inducing AEDs, such as phenobarbital, phenytoin and carbamazepine, which increases serum sex hormone binding globulin (SHBG) concentrations. This increase leads to diminished bioactivity of testosterone, which may result in diminished potency and thus reduced fertility. Men taking valproic acid have significantly higher dehydroepiandrosterone levels and lower gonadotropin concentration. Better understanding of molecular properties of AEDs and their effect on reproduction function will be the basis for on management of men suffering from epilepsy.
机译：目的：探讨癫痫，抗癫痫药物与生殖功能的关系。方法：通过计算机PubMed搜索确定相关文章。人工搜索选定文章的参考文献以获取其他引用。结论：癫痫患者的生殖内分泌激素紊乱发生率高于普通人群。它们表现为性欲减退，阳imp和不育。这些疾病可能是由癫痫病本身引起的，也可能是由于长期使用抗癫痫药（AED）或两者兼而有之。 AEDs可诱发各种激素异常;特别地，使用诱导肝酶的AED，例如苯巴比妥，苯妥英钠和卡马西平，会增加血清性激素结合球蛋白（SHBG）的浓度。这种增加导致睾丸激素的生物活性降低，这可能导致效力降低，从而导致生育力降低。服用丙戊酸的男性的脱氢表雄酮水平明显较高，促性腺激素浓度较低。更好地了解AED的分子特性及其对生殖功能的影响，将成为治疗男性癫痫患者的基础。

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