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首页> 外文期刊>Reproductive toxicology >Developmental toxicity evaluation of 1,2,3,4-butanetetracarboxylic acid in Sprague Dawley (CD) rats.
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Developmental toxicity evaluation of 1,2,3,4-butanetetracarboxylic acid in Sprague Dawley (CD) rats.

机译：1,2,3,4-丁烷四羧酸对Sprague Dawley（CD）大鼠的发育毒性评估。

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摘要

1,2,3,4-butanetetracarboxylic acid (BTCA), proposed as a formaldehyde substitute in the treatment of permanent press fabrics, was evaluated for developmental toxicity. Timed-mated CD rats (25 per group) received BTCA 250, 500, or 1000 mg/kg/day or vehicle (deionized/distilled water) by gavage on gestational days (gd) 6 through 19. Maternal feed and water consumption, body weight, and clinical signs were monitored throughout gestation. At termination (gd 20), confirmed-pregnant females (21 to 25 per group) were evaluated for clinical status and gestational outcome; live fetuses were examined for external, visceral, and skeletal malformations. One maternal death, reduced body weight, and reduced weight gain were noted at the high dose; confirmed pregnancy rates were 84 to 100% for each group. There were no treatment-related effects on fetal growth, survival, or morphologic development. The maternal toxicity NOAEL and LOAEL are 500 and 1000 mg/kg/day, respectively. The developmental toxicity NOAEL is > or = 1000 mg/kg/day, and the LOAEL was not established in this study.
机译：1,2,3,4-丁烷四甲酸（BTCA）被提议作为永久压榨织物的处理中的甲醛替代品，对其发育毒性进行了评估。定时配对的CD大鼠（每组25只）在妊娠第6至19天通过灌胃接受250、500或1000 mg / kg /天的BTCA或赋形剂（去离子/蒸馏水），母体的摄食和饮水量在整个妊娠期间监测体重和临床体征。在终止时（第20天），对已确诊怀孕的女性（每组21至25名）进行临床状态和妊娠结局的评估。检查活胎儿的外部，内脏和骨骼畸形。高剂量可导致一名产妇死亡，体重减轻和体重增加。每组的确诊妊娠率为84％至100％。对胎儿的生长，存活或形态发育没有治疗相关的影响。母体毒性NOAEL和LOAEL分别为500和1000 mg / kg /天。发育毒性NOAEL>或= 1000 mg / kg /天，并且LOAEL在本研究中尚未建立。

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